Association of NT-proBNP with all-cause mortality at 1, 5 and 10 years of follow-up (estimated with Cox proportional hazards models with a time-split at 2 years)
| Total follow-up | NT-proBNP group (pg/ml) | n/PY | Unadjusted (N=27 258) | Partially adjusted* (N=27 258) | Fully adjusted† (N=24 434) |
| HR (95% CI) | HR (95% CI) | HR (95% CI) | |||
| 1 year | <400 | 1761/6584 | 1.132 (1.061 to 1.208) | 1.283 (1.202 to 1.370) | 1.235 (1.150 to 1.327) |
| 400–1999.9 (Reference) | 1890/8086 | 1.000 | 1.000 | 1.000 | |
| 2000+ | 1846/5208 | 1.484 (1.392 to 1.583) | 1.404 (1.317 to 1.497) | 1.404 (1.310 to 1.506) | |
| 5 years | Years 0–2: | ||||
| <400 | 2198/10 776 | 1.082 (1.021 to 1.146) | 1.240 (1.171 to 1.314) | 1.214 (1.140 to 1.293) | |
| 400–1999.9 (Reference) | 2483/13 312 | 1.000 | 1.000 | 1.000 | |
| 2000+ | 2395/8449 | 1.485 (1.404 to 1.571) | 1.403 (1.326 to 1.484) | 1.414 (1.330 to 1.508) | |
| Years 2–5: | |||||
| <400 | 515/5569 | 0.793 (0.710 to 0.885) | 0.900 (0.806 to 1.006) | 0.891 (0.791 to 1.003) | |
| 400–1999.9 (Reference) | 812/6966 | 1.000 | 1.000 | 1.000 | |
| 2000+ | 641/4018 | 1.369 (1.235 to 1.519) | 1.350 (1.217 to 1.497) | 1.383 (1.237 to 1.548) | |
| 10 years | Years 0–2: | ||||
| <400 | 2198/10 776 | 1.082 (1.021 to 1.146) | 1.242 (1.172 to 1.316) | 1.218 (1.144 to 1.297) | |
| 400–1999.9 (Reference) | 2483/13 312 | 1.000 | 1.000 | 1.000 | |
| 2000+ | 2395/8449 | 1.485 (1.404 to 1.571) | 1.402 (1.325 to 1.483) | 1.414 (1.330 to 1.503) | |
| Years 2–10: | |||||
| <400 | 666/6978 | 0.793 (0.719 to 0.875) | 0.899 (0.815 to 0.992) | 0.890 (0.801 to 0.988) | |
| 400–1999.9 (Reference) | 1013/8450 | 1.000 | 1.000 | 1.000 | |
| 2000+ | 765/4832 | 1.322 (1.203 to 1.452) | 1.314 (1.196 to 1.443) | 1.343 (1.213 to 1.487) |
*Adjusted for age and sex.
†Adjusted for age, sex, ethnicity, IMD quintile, smoking status, systolic blood pressure, total cholesterol, body mass index, prior history of angina, myocardial infarction, ischaemic heart disease, diabetes, hypertension, stroke, atrial fibrillation, valve disease and calendar period (2004–2010, 2011–2018)
n, number of deaths; PY, number of person-years.