Table 3

Associations of HS-SIC with incident heart failure, overall and by sex

Total sampleWomenMen
HR*95% CIP valueSex interaction
P
HR*95% CIP valueHR*95% CIP value
Model 01.421.20 to 1.68<0.00010.0421.671.29 to 2.16<0.00011.160.92 to 1.470.22
Model 11.201.01 to 1.440.040.0471.461.13 to 1.90<0.011.040.82 to 1.320.72
Model 21.180.98 to 1.410.070.071.371.05 to 1.790.021.030.81 to 1.320.78
Model 31.040.85 to 1.260.720.161.300.98 to 1.730.070.880.68 to 1.130.32
  • Model 0: HS-SIC alone.

  • Model 1: HS-SIC+age + sex.

  • Model 2: Model 1+antihypertensive medication use.

  • Model 3: Model 2+body mass index, systolic blood pressure, diabetes, smoking and total/high-density lipoprotein cholesterol ratio.

  • *Estimates are per 1-SD for HS-SIC.

  • HS-SIC, high spectrum signal intensity coefficient.