Associations of HS-SIC with incident heart failure, overall and by sex
| Total sample | Women | Men | ||||||||
| HR* | 95% CI | P value | Sex interaction P | HR* | 95% CI | P value | HR* | 95% CI | P value | |
| Model 0 | 1.42 | 1.20 to 1.68 | <0.0001 | 0.042 | 1.67 | 1.29 to 2.16 | <0.0001 | 1.16 | 0.92 to 1.47 | 0.22 |
| Model 1 | 1.20 | 1.01 to 1.44 | 0.04 | 0.047 | 1.46 | 1.13 to 1.90 | <0.01 | 1.04 | 0.82 to 1.32 | 0.72 |
| Model 2 | 1.18 | 0.98 to 1.41 | 0.07 | 0.07 | 1.37 | 1.05 to 1.79 | 0.02 | 1.03 | 0.81 to 1.32 | 0.78 |
| Model 3 | 1.04 | 0.85 to 1.26 | 0.72 | 0.16 | 1.30 | 0.98 to 1.73 | 0.07 | 0.88 | 0.68 to 1.13 | 0.32 |
Model 0: HS-SIC alone.
Model 1: HS-SIC+age + sex.
Model 2: Model 1+antihypertensive medication use.
Model 3: Model 2+body mass index, systolic blood pressure, diabetes, smoking and total/high-density lipoprotein cholesterol ratio.
*Estimates are per 1-SD for HS-SIC.
HS-SIC, high spectrum signal intensity coefficient.