Table 3

Rate ratio of atrioventricular block in first-degree relatives to index case

Index case	Model 1 RR*	95% CI	P-value	Model 2 RR†	95% CI	P-value
Any father, mother or sibling	2.3	1.9 to 2.7	<0.001	2.1	1.8 to 2.5	<0.001
Any father, mother or sibling >50 years	2.1	1.7 to 2.5	<0.001	1.9	1.6 to 2.3	<0.001
Any father, mother or sibling <50 years	9.0	5.5 to 14.9	<0.001	8.0	4.8 to 13.4	<0.001
Mother	2.4	1.9 to 3.2	<0.001	2.2	1.7 to 2.9	<0.001
Mother >50 years	2.3	1.8 to 3.0	<0.001	2.1	1.6 to 2.8	<0.001
Mother <50 years	16.6	5.0 to 55.1	<0.001	15.8	4.8 to 52.3	<0.001
Daughters	2.7	1.7 to 4.2	<0.001	2.5	1.6 to 3.9	<0.001
Sons	2.3	1.7 to 3.2	<0.001	2.1	1.5 to 2.9	<0.001
Father	2.0	1.6 to 2.5	<0.001	1.9	1.5 to 2.4	<0.001
Father >50 years	1.9	1.5 to 2.5	<0.001	1.8	1.4 to 2.3	<0.001
Father <50 years	10.5	3.4 to 32.1	<0.001	10.0	3.3 to 30.4	<0.001
Daughters	2.0	1.3 to 3.0	<0.001	1.8	1.2 to 2.8	<0.001
Sons	2.0	1.5 to 2.7	<0.001	1.9	1.4 to 2.6	<0.001
Siblings	3.7	2.5 to 5.6	<0.001	3.5	2.3 to 5.4	<0.001

*Adjusted for age, sex and calendar time (model 1).
†Adjusted for age, sex, calendar time, heart failure, diabetes, atrial fibrillation/flutter and myocardial infarction (model 2).