Table 3

Diagnostic performance of different measures of hs-cTnT concentrations for myocardial infarction

Admission hs-cTnTHistorical hs-cTnT-adjusted admission hs-cTnTRelative change between historical and admission hs-cTnT
Calibration criterion vs admission hs-cTnTn/aSpecificityNo. patients ruled-inSensitivityPPVSpecificityNo. patients ruled-inSensitivityPPV
Cut-off level≥52 ng/L≥40.2≥44.4≥75.8≥30.9≥137%≥137%≥150%≥130%
Specificity, %(95% CI)91.2
(87.8 to 94.7)
91.2
(87.8 to 94.8)
91.9
(88.5 to 95.5)
94.8
(91.2 to 98.5)
89.1
(85.7 to 92.5)
91.2
(87.8 to 94.8)
91.3
(87.9 to 94.9)
92.5
(89.1 to 96.1)
90.7
(87.3–94.3)
Rule-in, n (%)3629 (13)3852 (14)3631 (13)2724 (9.8)4499 (16)3666 (13)3648 (13)3287 (12)3813 (14)
Sensitivity, %(95% CI)52.5
(50.6 to 54.6)
61.1
(58.8 to 63.5)
59.9
(57.6 to 62.2)
52.5
(50.6 to 54.6)
65.3
(62.9 to 67.8)
54.2
(52.2 to 56.4)
54.2
(52.1 to 56.3)
52.3
(50.4 to 54.4)
55.2
(53.2 to 57.4)
PPV, %
(95% CI)
38.9
(37.4 to 40.4)
42.6
(41.0 to 44.3)
44.3
(42.6 to 46.0)
51.8
(49.9 to 53.8)
39.0
(37.5 to 40.5)
39.7
(38.3 to 41.3)
39.9
(38.4 to 41.4)
42.8
(41.2 to 44.4)
38.9
(37.5 to 40.4)
MI≤30 days, n (%)1411 (39)1642 (43)1608 (44)1411 (51)1754 (39)1457 (40)1455 (40)1406 (43)1484 (39)
FP, n (%)2218 (61)2210 (57)2023 (56)1313 (49)2745 (61)2209 (60)2193 (60)1881 (57)2329 (61)
Efficacy, %
(95% CI)
87.4
(84.2 to 90.8)
88.3
(85.0 to 91.7)
88.8
(85.5 to 92.3)
90.7
(87.3 to 94.2)
86.8
(83.5 to 90.2)
87.6
(84.4 to 91.0)
87.7
(84.4 to 91.1)
88.6
(85.3 to 92.1)
87.3
(84.0 to 90.7)
LR+
(95% CI)
5.95
(5.73 to 6.18)
6.95
(6.69 to 7.22)
7.43
(7.16 to 7.72)
10.1
(9.68 to 10.4)
5.98
(5.75 to 6.21)
6.17
(5.94 to 6.41)
6.21
(6.00 to 6.47)
6.99
(6.73 to 7.26)
5.96
(5.74 to 6.19)
  • FP, false positives; hs-cTnT, high-sensitivity cardiac troponin T; LR+, positive likelihood ratio; MI, myocardial infarction; NPV, negative predictive value; PPV, positive predictive value.