Unadjusted | Adjusted model 1* | Adjusted model 2† | |||||||
HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | |
Primary endpoint | 0.760 | 0.638 to 0.906 | 0.002 | 0.757 | 0.635 to 0.903 | 0.002 | 0.834 | 0.698 to 0.997 | 0.046 |
All-cause death | 0.838 | 0.684 to 1.027 | 0.088 | 0.853 | 0.696 to 1.047 | 0.128 | 0.944 | 0.768 to 1.160 | 0.583 |
Cardiovascular death | 0.782 | 0.598 to 1.020 | 0.071 | 0.791 | 0.604 to 1.035 | 0.088 | 0.872 | 0.664 to 1.145 | 0.320 |
Heart failure hospitalisation | 0.737 | 0.603 to 0.900 | 0.003 | 0.726 | 0.593 to 0.888 | 0.002 | 0.791 | 0.645 to 0.970 | 0.024 |
*Adjusted for randomisation group, age, gender and race.
†Adjusted for randomisation group, age, gender, race, previous heart failure hospitalisation, diuretics use, estimated glomerular filtration rate, left ventricular ejection fraction and serum sodium.
HR, hazard ratio.;