Table 5

Beta-blockers indicated in HFrEF

Beta-blockerInitiation dose (mg)Target dose (mg)
Bisoprolol1.25 once daily10 once daily
Carvedilol3.125 two times a day25–50 two times a day*
Metoprolol succinate (CR/XL)†12.5 once daily200 once daily
Nebivolol1.25 once daily10 once daily
  • *50 mg two times a day if weight >85 kg.

  • †Extended-release preparations not available in the UK—no data to support the use of standard-release preparations of metoprolol tartarate.

  • HFrEF, heart failure with reduced ejection fraction.