Endpoints | Proximal LAD | Non-proximal LAD | P value for interaction | ||||
n | HR (95% CI) | P value | n | HR (95% CI) | P value | ||
All-cause death at 10 years | 136/559 | 1.39 (0.99 to 1.95) | 0.055 | 127/529 | 1.47 (1.03 to 2.09) | 0.035 | 0.837 |
All-cause death at maximum follow-up | 170/559 | 1.36 (1.01 to 1.84) | 0.044 | 160/529 | 1.35 (0.98 to 1.84) | 0.063 | 0.955 |
MACCE at 5 years | 164/559 | 1.86 (1.36 to 2.55) | <0.001 | 159/529 | 1.54 (1.11 to 2.12) | 0.009 | 0.408 |
All-cause death at 5 years | 63/559 | 1.74 (1.04 to 2.89) | 0.033 | 61/529 | 1.57 (0.93 to 2.64) | 0.093 | 0.780 |
Cardiac death at 5 years | 33/559 | 3.96 (1.72 to 9.13) | 0.001 | 35/529 | 1.50 (0.76 to 2.98) | 0.246 | 0.078 |
MI at 5 years | 35/559 | 6.52 (2.53 to 16.81) | <0.001 | 37/529 | 1.90 (0.95 to 3.78) | 0.068 | 0.038 |
Stroke at 5 years | 18/559 | 0.53 (0.20 to 1.40) | 0.199 | 14/529 | 1.59 (0.53 to 4.76) | 0.403 | 0.136 |
Revascularisation at 5 years | 93/559 | 2.46 (1.59 to 3.79) | <0.001 | 97/529 | 1.99 (1.30 to 3.06) | 0.002 | 0.501 |
HRs are calculated with the ratios of the PCI arm compared with the CABG arm.
‘n’ refers to the number of patients having events/total number of patients in the model.
P values highlighted in bold suggest statistical significance (p<0.05).
CABG, coronary artery bypass grafting; LAD, left anterior descending artery; MACCE, major adverse cardiac or cerebrovascular event; MI, myocardial infarction; PCI, percutaneous coronary intervention.