Pressure–flow relationships
| Healthy (33) | AMI (52) | MR (43) | AS (40) | P value | |
| Rest→peak | |||||
| ∆PAWP/∆CO (mm Hg/L/min) | 1.3±1.1* | 2.3±0.7*† | 1.9±1.4* | 3.0±1.3*†‡§ | <0.0001 |
| ∆mPAP/∆CO (mm Hg/L/min) | 2.0±1.5* | 2.8±1.3* | 3.0±1.6*† | 4.5±1.8*†‡§ | <0.0001 |
| Rest→25 W | |||||
| ∆PAWP_25 W/∆CO_25 W (mm Hg/L/min) | 2.2±1.5 | 3.3±2.2 | 2.9±2.7 | 4.5±4.5† | 0.01 |
| ∆mPAP_25 W/∆CO_25 W (mm Hg/L/min) | 3.1±1.8 | 4.9±3.0 | 5.8±4.3 | 7.6±7.5†‡ | 0.0009 |
Unadjusted analysis of variance was used to assess between-group differences, and Tukey’s honestly significant difference test was used to determine which group means differed for normally distributed data. Paired t-test was used to test between ∆peak and ∆25 W.
*P<0.05 vs ∆25 W.
†P<0.05 vs healthy.
‡P<0.05 vs MR.
§P<0.05 vs AMI.
AMI, acute myocardial infarction; AS, aortic stenosis; CO, cardiac output; ∆CO, change in cardiac output; mPAP, mean pulmonary arterial pressure; MR, mitral regurgitation; ∆PAWP, change in pulmonary arterial wedge pressure; PAWP, pulmonary arterial wedge pressure.