Original | IPTW-adjusted | |||||
No. of events (rate*) | ||||||
Outcomes | Preservation (n=804) | Closure (n=836) | OR or HR/sHR (95% CI) | P value | OR or HR/sHR (95% CI) | P value |
Early outcomes | ||||||
Early death | 20 (2.5) | 30 (3.6) | 0.69 (0.38to 1.21) | 0.197 | 0.75 (0.43 to 1.28) | 0.287 |
Early complications | ||||||
LCOS requiring MCS | 21 (2.6) | 22 (2.6) | 0.99 (0.54 to 1.82) | 0.980 | 1.03 (0.57 to 1.88) | 0.911 |
Early stroke | 14 (1.7) | 20 (2.4) | 0.72 (0.36 to 1.43) | 0.357 | 1.21 (0.63 to 2.34) | 0.561 |
Bleeding | 37 (4.6) | 53 (6.3) | 0.71 (0.46 to 1.09) | 0.124 | 0.73 (0.47 to 1.13) | 0.164 |
From LAA | NA | 8 (1.0) | NA | NA | NA | NA |
From other focus | 37 (4.6) | 45 (5.4) | 0.85 (0.54 to 1.32) | 0.469 | 0.84 (0.53 to 1.32) | 0.456 |
New-onset dialysis | 31 (3.9) | 36 (4.3) | 0.89 (0.54 to 1.45) | 0.645 | 1.05 (0.65 to 1.69) | 0.849 |
Sternal wound infection | 7 (0.9) | 10 (1.2) | 0.73 (0.26 to 1.90) | 0.517 | 0.85 (0.31 to 2.26) | 0.742 |
Early AF recurrence (<3 months) | 499 (62.1) | 589 (70.5) | 0.69 (0.56 to 0.84) | <0.001 | 1.05 (0.86 to 1.30) | 0.615 |
Overall outcomes | ||||||
All-cause death | 105 (1.7) | 144 (2.8) | 0.61 (0.48 to 0.79) | <0.001 | 0.80 (0.61 to 1.05) | 0.111 |
Stroke | 41 (0.9) | 46 (1.2) | 0.76 (0.50 to 1.15) | 0.197 | 0.85 (0.52 to 1.39) | 0.512 |
Early outcomes are defined as those occurring within 30 days of surgery, and presented as ORs; overall outcomes are presented as HR or sHR.
*Calculated as the percentage for early outcomes, and per 100 patent-years for overall outcomes.
AF, atrial fibrillation; IPTW, inverse-probability-of-treatment weighting; LAA, left atrial appendage; LCOS, low cardiac output syndrome; MCS, mechanical circulatory support; NA, not applicable; sHR, subdistributional HR.