Table 2

Early and overall clinical outcomes of the left atrial appendage preservation versus closure groups

OriginalIPTW-adjusted
No. of events (rate*)
OutcomesPreservation
(n=804)
Closure
(n=836)
OR or HR/sHR (95% CI)P valueOR or HR/sHR (95% CI)P value
Early outcomes
Early death20 (2.5)30 (3.6)0.69 (0.38to 1.21)0.1970.75 (0.43 to 1.28)0.287
Early complications
 LCOS requiring MCS21 (2.6)22 (2.6)0.99 (0.54 to 1.82)0.9801.03 (0.57 to 1.88)0.911
 Early stroke14 (1.7)20 (2.4)0.72 (0.36 to 1.43)0.3571.21 (0.63 to 2.34)0.561
 Bleeding37 (4.6)53 (6.3)0.71 (0.46 to 1.09)0.1240.73 (0.47 to 1.13)0.164
 From LAANA8 (1.0)NANANANA
 From other focus37 (4.6)45 (5.4)0.85 (0.54 to 1.32)0.4690.84 (0.53 to 1.32)0.456
 New-onset dialysis31 (3.9)36 (4.3)0.89 (0.54 to 1.45)0.6451.05 (0.65 to 1.69)0.849
 Sternal wound infection7 (0.9)10 (1.2)0.73 (0.26 to 1.90)0.5170.85 (0.31 to 2.26)0.742
Early AF recurrence (<3 months)499 (62.1)589 (70.5)0.69 (0.56 to 0.84)<0.0011.05 (0.86 to 1.30)0.615
Overall outcomes
All-cause death105 (1.7)144 (2.8)0.61 (0.48 to 0.79)<0.0010.80 (0.61 to 1.05)0.111
Stroke41 (0.9)46 (1.2)0.76 (0.50 to 1.15)0.1970.85 (0.52 to 1.39)0.512
  • Early outcomes are defined as those occurring within 30 days of surgery, and presented as ORs; overall outcomes are presented as HR or sHR.

  • *Calculated as the percentage for early outcomes, and per 100 patent-years for overall outcomes.

  • AF, atrial fibrillation; IPTW, inverse-probability-of-treatment weighting; LAA, left atrial appendage; LCOS, low cardiac output syndrome; MCS, mechanical circulatory support; NA, not applicable; sHR, subdistributional HR.