Association of birth weight with incident outcomes (baseline cohort)
| Univariate | Age and sex adjusted | Fully adjusted | |
| All-cause mortality | 1.02 (0.98 to 1.05) p=0.41 | 0.97 (0.94 to 1.00) p=0.073 | 0.98 (0.95 to 1.01) p=0.210 |
| CVD death | 1.01 (0.92 to 1.10) p=0.88 | 0.90 (0.83 to 0.97) p=0.010 | 0.91 (0.84 to 0.99) p=0.028 |
| IHD death | 1.02 (0.91 to 1.16) p=0.70 | 0.86 (0.77 to 0.96) p=0.009 | 0.88 (0.79 to 0.98) p=0.020 |
| Fatal AMI | 1.04 (0.86 to 1.26) p=0.67 | 0.89 (0.75 to 1.05) p=0.16 | 0.90 (0.76 to 1.06) p=0.216 |
| Incident AMI | 1.00 (0.94 to 1.06) p=0.90 | 0.89 (0.84 to 0.93) p=1.0×10−5 | 0.90 (0.85 to 0.95) p=7.0×10–5 |
All cause-mortality associations are estimated using Cox proportional hazard models, results are expressed as HR (95% CI) and p value. For all other outcomes, competing risk regression models are used with results expressed as subdistribution HRs (95% CI) and p values. For all outcomes, results are per 1 kg increase in birth weight. Fully adjusted models include adjustment for age, sex, social deprivation, maternal diabetes, maternal hypertension, maternal smoking and paternal diabetes. Statistical significance level is p<0.01, corrected for five outcomes.
AMI, acute myocardial infarction; CVD, cardiovascular disease; IHD, ischaemic heart disease.