Baseline participants’ characteristics
| Baseline cohort (n=258 787) | CMR subset (n=19 314) | |
| Age | 56 (49, 62) | 62 (56, 68) |
| Men | 100 540 (38.9%) | 8074 (41.8%) |
| Birth weight (kg) | 3.34 (±0.60) | 3.37 (±0.57) |
| Diabetes | 10 760 (4.2%) | 445 (2.3%) |
| Hypertension | 64 724 (25.0%) | 3489 (18.1%) |
| Hypercholesterolaemia | 40 297 (15.6%) | 2141 (11.1%) |
| BMI (kg/m2) | 27.3 (±4.9) | 25.9 (23.5, 28.8) |
| Smoking (current) | 25 388 (9.8%) | 1154 (6.0%) |
| Townsend deprivation score | −2.33 (−3.74, 0.10) | −2.69 (−3.9, 0.71) |
| Maternal smoking | 68 654 (29.6%) | 5193 (26.9%) |
| Paternal diabetes | 23 566 (9.1%) | 1882 (9.7%) |
| Maternal diabetes | 23 889 (9.2%) | 1788 (9.3%) |
| Maternal hypertension | 85 355 (33.0%) | 6577 (34.1%) |
| LVM/LVEDV (g/mL) | – | 0.58 (±0.09) |
| LVSVi (mL/m2) | – | 46.9 (±8.2) |
| LVGFI (%) | – | 0.48 (±0.07) |
| GLS (%) | – | −18.6 (±2.7) |
| LAEF (%) | – | 61.6 (±8.8) |
BMI, body mass index; CMR, cardiovascular magnetic resonance; GLS, global longitudinal strain; LAEF, left atrial ejection fraction; LVGFI, left ventricular global function index; LVM/LVEDV, left ventricular mass to left ventricular end-diastolic volume ratio; LVSVi, left ventricular stroke volume index.