Interactions with time since COVID-19 diagnosis
| Incident disease | Interaction with time* | Events within 30 days | Events after 30 days |
| Interaction HR (95% CI) | HR (95% CI) | HR (95% CI) | |
| MI | 0.996 (0.989 to 1.003) P=0.30 | – | – |
| Stroke | 0.992 (0.984 to 1.001) P=0.07 | – | – |
| Heart failure | 0.992 (0.988 to 0.997) P=0.001 | 11.03 (5.97 to 20.38) P<0.0001 | 2.78 (1.71 to 4.51) P<0.0001 |
| AF | 0.986 (0.981 to 0.992) P<0.0001 | 15.45 (8.87 to 26.91) P<0.0001 | 1.72 (1.11 to 2.67) P=0.015 |
| VTE | 0.984 (0.977 to 0.992) P<0.0001 | 66.78 (24.7 to 180.5) P<0.0001 | 3.97 (2.10 to 7.53) P<0.0001 |
| Pericarditis | 0.989 (0.979 to 0.999) P=0.04 | 24.74 (3.22 to 189.9) P=0.002 | 4.64 (1.63 to 13.19) P=0.004 |
| Mortality | |||
| All-cause | 0.020 (0.007 to 0.056) P<0.0001 | 101.1 (64.9 to 157.3) P<0.0001 | 9.73 (7.13 to 13.28) P<0.0001 |
| CVD | 0.994 (0.987 to 1.001) P=0.12 | – | – |
| IHD | 1.00 (0.992 to 1.009) P=0.945 | – | – |
*For outcomes with a significant time interaction term, we examine associations stratified by 30 days before/after infection date to examine whether observed risks extend beyond the acute postinfection period.
AF, atrial fibrillation; CVD, cardiovascular disease; IHD, ischaemic heart disease; MI, myocardial infarction; VTE, venous thromboembolism;