Table 4

Interactions with time since COVID-19 diagnosis

Incident diseaseInteraction with time*Events within 30 daysEvents after 30 days
Interaction HR (95% CI)HR (95% CI)HR (95% CI)
 MI0.996 (0.989 to 1.003)
P=0.30
 Stroke0.992 (0.984 to 1.001)
P=0.07
 Heart failure0.992 (0.988 to 0.997)
P=0.001
11.03 (5.97 to 20.38)
P<0.0001
2.78 (1.71 to 4.51)
P<0.0001
 AF0.986 (0.981 to 0.992)
P<0.0001
15.45 (8.87 to 26.91)
P<0.0001
1.72 (1.11 to 2.67)
P=0.015
 VTE0.984 (0.977 to 0.992)
P<0.0001
66.78 (24.7 to 180.5)
P<0.0001
3.97 (2.10 to 7.53)
P<0.0001
 Pericarditis0.989 (0.979 to 0.999)
P=0.04
24.74 (3.22 to 189.9)
P=0.002
4.64 (1.63 to 13.19)
P=0.004
Mortality
 All-cause0.020 (0.007 to 0.056)
P<0.0001
101.1 (64.9 to 157.3)
P<0.0001
9.73 (7.13 to 13.28)
P<0.0001
 CVD0.994 (0.987 to 1.001)
P=0.12
 IHD1.00 (0.992 to 1.009)
P=0.945
  • *For outcomes with a significant time interaction term, we examine associations stratified by 30 days before/after infection date to examine whether observed risks extend beyond the acute postinfection period.

  • AF, atrial fibrillation; CVD, cardiovascular disease; IHD, ischaemic heart disease; MI, myocardial infarction; VTE, venous thromboembolism;