Table 1

Dose reduction criteria of NOACs18

NOACDose reduction criteriaReduced dose
DabigatranCreatinine clearance: 50 mL/minVariable doses below full 110 mg dose recommended in ESC guidelines
RivaroxabanCreatinine clearance: 50 mL/min15 mg once a day
Apixaban2 of 3 criteria: age ≥80 years, weight ≤60 kg, creatinine ≥1.5 mg/dL2.5 mg two times a day
EdoxabanCreatinine clearance: ≤50 mL/min30 mg once a day
  • NOAC, non-vitamin K antagonist oral anticoagulant.