Dose reduction criteria of NOACs18
| NOAC | Dose reduction criteria | Reduced dose |
| Dabigatran | Creatinine clearance: 50 mL/min | Variable doses below full 110 mg dose recommended in ESC guidelines |
| Rivaroxaban | Creatinine clearance: 50 mL/min | 15 mg once a day |
| Apixaban | 2 of 3 criteria: age ≥80 years, weight ≤60 kg, creatinine ≥1.5 mg/dL | 2.5 mg two times a day |
| Edoxaban | Creatinine clearance: ≤50 mL/min | 30 mg once a day |
NOAC, non-vitamin K antagonist oral anticoagulant.