Association of phenogroups with mortality risk after MV surgery
| Derivation cohort (n=1629) | Entire cohort (n=2321) | |||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Univariable analysis | ||||
| Group 1 | 1.00 (reference) | – | 1.00 (reference) | – |
| Group 2 | 2.78 (1.22 to 6.35) | 0.015 | 3.48 (1.65 to 7.36) | 0.001 |
| Group 3 | 5.93 (2.81 to 12.52) | <0.001 | 6.40 (3.14 to 13.05) | <0.001 |
| Group 4 | 5.34 (2.67 to 10.68) | <0.001 | 6.45 (3.30 to 12.64) | <0.001 |
| Group 5 | 16.78 (8.61 to 32.69) | <0.001 | 18.78 (9.84 to 35.86) | <0.001 |
| Multivariable analysis** | ||||
| Group 1 | 1.00 (reference) | – | 1.00 (reference) | – |
| Group 2 | 1.04 (0.39 to 2.77) | 0.944 | 1.45 (0.62 to 3.43) | 0.392 |
| Group 3 | 2.61 (1.08 to 6.32) | 0.034 | 3.24 (1.45 to 7.25) | 0.004 |
| Group 4 | 1.85 (0.81 to 4.20) | 0.144 | 2.08 (0.97 to 4.46) | 0.058 |
| Group 5 | 3.16 (1.23 to 8.15) | 0.017 | 3.55 (1.53 to 8.24) | 0.003 |
*Adjusted for variables included in the MIDA score (age, atrial fibrillation, symptoms, LV end-systolic diameter, LV ejection fraction, LA dimension and TR peak velocity).
LA, left atrium; LV, left ventricular; MIDA, Mitral Regurgitation International Database; MV, mitral valve; TR, tricuspid regurgitation.