Risk of developing obstructive coronary artery stenosis with concomitant reduced left ventricular ejection fraction (LVEF) <50% among women with versus without a history of pre-eclampsia, January 2002 to March 2020*
| Exposure group | Number of women with obstructive coronary artery stenosis and reduced LVEF (incidence rate per 10 000 person years, 95% CI) | Unadjusted HR (95% CI) | Fully adjusted HR (95% CI)† |
| Women without pre-eclampsia (n=1 358 335) | 140 (0.11, 0.09 to 0.13) | 1.00 (referent) | 1.00 (referent) |
| Women with pre-eclampsia (n=42 140) | 22 (0.54, 0.34 to 0.81) | 4.64 (2.96 to 7.28) | 2.03 (1.27 to 3.24) |
The time zero index date starts 42 days after the index birth hospitalisation discharge date.
An overview of the study findings can be found in the central figure (figure 3).
*Left ventriculography was performed among 263 of the 474 women (55.5%) in the pre-eclampsia group who underwent coronary angiography, and 3086 of the 5238 women (58,9%) in the non-pre-eclampsia group who had coronary angiography.
†Adjusted for maternal age, parity, neighbourhood income quintile (1 or missing, 2, 3, 4, 5), residence (rural, urban or missing) at the time of the index delivery, as well as diabetes mellitus, chronic hypertension, renal disease, illicit drug/tobacco use, and dyslipidaemia within 365 days preceding the index date, and further adjusted for time-varying diabetes mellitus, chronic hypertension, renal disease, drug dependence or tobacco use, and dyslipidaemia—each arising at time zero onwards up to the day before the coronary angiography.