Risk of developing obstructive coronary artery stenosis among women with versus without a history of pre-eclampsia and a concomitant preterm live birth before 37 weeks’ gestation
| Exposure group | Number of women with obstructive coronary artery stenosis (incidence rate per 10 000 person years, 95% CI) | Unadjusted HR (95% CI) | Fully adjusted HR (95% CI)* |
| Neither pre-eclampsia nor concomitant preterm birth (n=1211 021) | 965 (0.85, 0.80 to 0.91) | 1.00 (referent) | 1.00 (referent) |
| No pre-eclampsia, but had a preterm birth (n=141 661) | 250 (1.80, 1.58 to 2.03) | 2.09 (1.82 to 2.41) | 1.63 (1.42 to 1.88) |
| Pre-eclampsia, but no preterm birth (n=27 208) | 88 (3.28, 2.63 to 4.04) | 3.51 (2.82 to 4.37) | 1.81 (1.45 to 2.26) |
| Pre-eclampsia and concomitant preterm birth (n=14 580) | 95 (6.93, 5.61 to 8.48) | 8.10 (6.56 to 10.01) | 3.11 (2.51 to 3.87) |
This analysis was limited to women with a live birth in the index pregnancy, January 2002 to March 2020. The time zero index date starts 42 days after the index birth hospitalisation discharge date.
*Adjusted for maternal age, parity, neighbourhood income quintile (1 or missing, 2, 3, 4, 5), residence (rural, urban or missing) at the time of the index delivery, as well as diabetes mellitus, chronic hypertension, renal disease, illicit drug/tobacco use, and dyslipidaemia within 365 days preceding the index date, and further adjusted for time-varying diabetes mellitus, chronic hypertension, renal disease, drug dependence or tobacco use, and dyslipidaemia—each arising at time zero onward up to the day before the coronary angiography.