Baseline participant characteristics
| Cases | Controls | Breast | Lung | Prostate | Colorectal | Uterus | Haem | |
| N | 18 714 | 18 714 | 9531* | 313 | 3291 | 2412 | 937 | 2230 |
| Age | 62 (57–66) | 62 (57–66) | 61 (56–65) | 62 (58–66) | 65 (62–67) | 63 (59–66) | 63 (59–66) | 60 (53–65) |
| Men | 6095 (32.6) | 6095 (32.6) | 0 (0) | 170 (54.3) | 3291 (100) | 1383 (57.3) | 0 (0) | 1251 (56.1) |
| Women | 12 619 (67.4) | 12 619 (67.4) | 9531 (100) | 143 (45.7) | 0 (0) | 1029 (42.7) | 937 (100) | 979 (43.9) |
| White ethnicity | 18 002 (96.7) | 18 025 (96.7) | 9201 (96.9) | 301 (96.2) | 3143 (96.1) | 2324 (96.6) | 910 (97.5) | 2146 (96.7) |
| BAME | 617 (3.3) | 611 (3.3) | 299 (3.2) | 12 (3.8) | 129 (3.9) | 81 (3.4) | 23 (2.5) | 73 (3.3) |
| Townsend score | −2.3 (−3.7 to 0.3) | −2.3 (−3.7 to 0.3) | −2.3 (−3.7 to 0.2) | −0.7 (−3.3 to 2.5) | −2.4 (−3.8 to −0.1) | −2.2 (−3.7 to 0.4) | −2.2 (−3.6 to 0.0) | −2.2 (−3.6 to 0.5) |
| Degree or professional qualification | 8329 (45.5) | 8300 (45.4) | 4259 (45.5) | 96 (32.1) | 1513 (47.1) | 1022 (43.3) | 382 (42.0) | 1057 (48.5) |
| SBP (mm Hg) | 140.2±19.2 | 140.1±19.1 | 138.5±19.4 | 137.7±19.3 | 145.0±17.8 | 142.6±19.2 | 141.2±18.7 | 137.5±18.9 |
| DBP (mm Hg) | 82.0±10.1 | 82.0±10.0 | 81.4±9.9 | 81.5±11.2 | 84.0±9.9 | 82.6±10.1 | 82.1±9.6 | 81.1±10.6 |
| HR (bpm) | 70.5 (63.5–78.5) | 70(63-78) | 71.5(65-79) | 75 (67–83.5) | 67.5 (60.5–75.5) | 69.5 (62.5–77.5) | 71(64-78) | 70.5(63-80) |
| BMI (kg/m2) | 26.8 (24.2–30.0) | 26.7 (24.1–29.9) | 26.4 (23.7–29.7) | 26.7 (24.3–30.1) | 27.4 (25.1–30.0) | 27.2 (24.7–30.2) | 28.4 (24.7–33.7) | 26.8 (24.2–30.0) |
| Physical activity (METS/week) | 1695 (754–3426) | 1742 (782–3471) | 1695 (777–3336) | 1175 (375–2799) | 1874 (817–3848) | 1626 (704–3412) | 1624 (710–3506) | 1578 (693–3279) |
| Ever smoked | 8909 (48.0) | 9141 (49.2) | 4225 (44.6) | 257 (82.9) | 1725 (53.0) | 1304 (54.4) | 342 (36.8) | 1056 (47.6) |
| HbA1c (mmol/mol) | 36 (33.5–38.7) | 35.9 (33.4–38.5) | 36 (33.7–38.5) | 37 (34.1–39.7) | 36 (33.4–38.6) | 36 (33.4–39.1) | 36.4 (34.1–39.2) | 35.5 (32.8–38.4) |
| Random glucose (mmol/L) | 5.0 (4.7–5.4) | 5.0 (4.6–5.4) | 5.0 (4.7–5.4) | 4.9 (4.6–5.4) | 5.0 (4.7–5.5) | 5.1 (4.7–5.5) | 5.0 (4.7–5.5) | 5.0 (4.6–5.4) |
| Total cholesterol (mmol/L) | 5.8±1.2 | 5.8±1.2 | 6.0±1.2 | 5.6±1.3 | 5.4±1.1 | 5.6±1.2 | 5.9±1.2 | 5.6±1.2 |
| HDL (mmol/L) | 1.4 (1.2–1.7) | 1.4 (1.2–1.7) | 1.6 (1.3–1.8) | 1.3 (1.1–1.6) | 1.3 (1.1–1.5) | 1.4 (1.1–1.7) | 1.5 (1.3–1.7) | 1.3 (1.1–1.6) |
| LDL (mmol/L) | 3.5 (2.9–4.2) | 3.6 (2.9–4.2) | 3.6 (3.0–4.3) | 3.4 (2.8–4.1) | 3.4 (2.8–4.0) | 3.4 (2.8–4.1) | 3.6 (3.0–4.3) | 3.5 (2.9–4.1) |
| Triglyceride level (mmol/L) | 1.6 (1.1–2.2) | 1.5 (1.1–2.2) | 1.5 (1.1–2.1) | 1.7 (1.2–2.3) | 1.7 (1.2–2.4 | 1.7 (1.2–2.4) | 1.6 (1.2–2.2) | 1.6 (1.1–2.4) |
| Diabetes | 1222 (6.5) | 1238 (6.6) | 463 (4.9) | 31 (9.9) | 264 (8.0) | 211 (8.8) | 89 (9.5) | 164 (7.4) |
| Hypertension | 6421 (34.3) | 6443 (34.4) | 2761 (29.0) | 108 (34.5) | 1499 (45.6) | 953 (39.5) | 360 (38.4) | 740 (33.2) |
| High cholesterol | 5659 (30.2) | 5627 (30.1) | 2272 (23.8) | 115 (36.7) | 1431 (43.5) | 882 (36.6) | 304 (32.4) | 655 (29.4) |
Count variables are shown as N (%). Continuous variables are shown as mean±SD or median (IQR) if skewed.
*39 males excluded
BAME, black, Asian and minority ethnic; BMI, body mass index; DBP, diastolic blood pressure; Haem, haematological; HbA1c, glycated haemoglobin; HDL, high density lipoprotein; LDL, low density lipoprotein; MET, metabolic equivalent; SBP, systolic blood pressure.