Baseline characteristics, comorbidities and medical therapy of matched and unmatched patients with moderate and asymptomatic severe AS, divided into heart valve clinic versus standard of care
| Unmatched | Matched | ||||||
| Total (N=2129) | Heart valve clinic (n=251) | Standard of care (n=1878) | P value | Heart valve clinic (n=156) | Standard of care (n=156) | P value | |
| Age, n (%) | 76.5±12.4 | 71±13.3 | 77.2±12.2 | <0.001 | 72.8±11.3 | 72±13.5 | 0.559 |
| Female sex, n (%) | 942 (44.2) | 99 (39.4) | 843 (44.9) | 0.118 | 58 (37.2) | 53 (34) | 0.636 |
| BMI (kg/m2) | 26.3 (23.7–29.6) | 26.9 (24.1–29.7) | 26.3 (23.7–29.6) | 0.228 | 27.1 (24.5–29.4) | 26.4 (23.6–29.3) | 0.321 |
| HBP, n (%) | 720 (33.8) | 70 (27.9) | 650 (34.6) | 0.041 | 52 (33.3) | 49 (31.4) | 0.809 |
| T2DM, n (%) | 559 (26.2) | 55 (21.9) | 504 (26.8) | 0.112 | 40 (25.6) | 43 (27.6) | 0.798 |
| AF, n (%) | 731 (34.3) | 80 (31.9) | 651 (34.7) | 0.421 | 51 (32.7) | 42 (26.9) | 0.322 |
| COPD, n (%) | 387 (18.2) | 43 (17.1) | 344 (18.3) | 0.711 | 28 (17.9) | 30 (19.2) | 0.884 |
| Cancer, n (%) | 348 (16.3) | 38 (15.1) | 310 (16.5) | 0.646 | 24 (15.4) | 27 (17.3) | 0.759 |
| CAD, n (%) | 581 (27.3) | 48 (19.1) | 533 (28.4) | 0.003 | 34 (21.8) | 35 (22.4) | 0.999 |
| Pre-HF, n (%) | 75 (3.5) | 3 (1.2) | 72 (3.8) | 0.052 | 3 (1.9) | 4 (2.6) | 0.999 |
| CABG, n (%)* | 34 (1.6) | 4 (1.6) | 30 (1.6) | 0.999 | 4 (2.6) | 5 (3.2) | 0.999 |
| Pre-MVR, n (%)* | 28 (1.3) | 6 (2.4) | 22 (1.2) | 0.132 | 3 (1.9) | 1 (0.6) | 0.623 |
| GFR (mL/min) | 61±22.3 | 67.2±19.2 | 58±22.4 | <0.001 | 67±19 | 67.3±20 | 0.907 |
| ACE-I, n (%) | 656 (30.8) | 76 (30.3) | 580 (30.9) | 0.903 | 47 (30.1) | 52 (33.3) | 0.627 |
| ARBs, n (%) | 1022 (48) | 122 (48.6) | 900 (47.9) | 0.892 | 76 (48.7) | 86 (55.1) | 0.308 |
| MRAs, n (%) | 810 (38) | 88 (35.1) | 722 (38.4) | 0.333 | 69 (44.2) | 66 (42.3) | 0.819 |
| Beta-blockers, n (%) | 1211 (56.9) | 149 (59.4) | 1062 (56.5) | 0.437 | 101 (64.7) | 97 (62.2) | 0.724 |
| Statins, n (%) | 1280 (60.1) | 152 (60.6) | 1128 (60.1) | 0.935 | 109 (69.9) | 112 (71.8) | 0.803 |
Continuous variables are presented as mean (SD) or median (LQ–UQ), when indicated; categorical ones are presented as n (%).
*Differences in categorical variables were analysed using Fisher’s exact test.
ACE-I, ACE inhibitor; AF, atrial fibrillation; ARBs, angiotensin receptor blockers; AS, aortic stenosis; BMI, body mass index; CABG, coronary artery bypass graft surgery; CAD, coronary artery disease; COPD, chronic obstructive pulmonary disease; GFR, glomerular filtration rate; HBP, hypertension; HF, heart failure; LQ, lower quartile; MRAs, mineralocorticoid receptor antagonists (aldosterone blockers); MVR, mitral valve repair; T2DM, type 2 diabetes mellitus; UQ, upper quartile.