Primary and secondary outcomes in the intention-to-treat analysis
| Outcome | Beta-blockers (n=34 253) Events/100 patient-years (incidence rate) | No beta-blockers (n=9365) Events/100 patient-years (incidence rate) | Hazard ratio (95% CI) for beta-blockers (unadjusted) | Hazard ratio (95% CI) for beta-blockers (adjusted) |
| Primary composite outcome | 6475/1709 (3.8) | 2028/414 (4.9) | 0.76 (0.73 to 0.80) | 0.99 (0.93 to 1.04) |
| All-cause mortality | 2872/1733 (1.7) | 945/420 (2.3) | 0.72 (0.67 to 0.78) | 1.00 (0.92 to 1.09) |
| Myocardial infarction | 2598/1733 (1.5) | 787/420 (1.9) | 0.82 (0.76 to 0.89) | 1.00 (0.91 to 1.09) |
| Unscheduled revascularisation | 1415/1709 (0.8) | 372/414 (0.9) | 0.95 (0.84 to 1.06) | 0.96 (0.85 to 1.09) |
| Heart failure hospitalisation | 462/1733 (0.3) | 145/420 (0.4) | 0.78 (0.65 to 0.94) | 1.05 (0.85 to 1.31) |
| Other secondary outcomes | ||||
| Cardiovascular mortality | 760/1481 (0.5) | 270/355 (0.8) | 0.68 (0.59 to 0.78) | 0.98 (0.83 to 1.14) |
| Stroke | 1136/1704 (0.7) | 318/412 (0.8) | 0.88 (0.78 to 1.00) | 1.02 (0.89 to 1.17) |
| Negative control outcome | ||||
| Pneumonia | 1314/1707 (0.8) | 375/414 (0.9) | 0.86 (0.77 to 0.97) | 1.07 (0.94 to 1.22) |
The primary composite outcome was a composite of all-cause mortality, myocardial infarction, hospitalisation for heart failure and unscheduled coronary revascularisation. Person time and incidence rate is given in 100 person-years. Hazard ratios are given with 95% confidence intervals. The no beta-blockers group is the reference group.