Table 1

Baseline characteristics of all participants in the UK Biobank cohort and the published QRISK3 derivation cohort6 by sex

UK Biobank female (N=233 233)QResearch derivation female (N=4 019 956)UK Biobank male (N=170 137)QResearch derivation male (N=3 869 847)
Age (years), mean (SD)56.0 (8.0)43.3 (15.3)55.8 (8.2)42.6 (14.0)
Systolic blood pressure (mm Hg), mean (SD)134.4 (19.2)123.2 (18.2)140.4 (17.4)129.2 (16.3)
 Missing897 (0.4)692 511 (17.2)510 (0.3)1 225 165 (31.7)
Measure of systolic blood pressure variability (SD of repeated measures), mean (SD)5.4 (4.5)9.3 (6.2)5.2 (4.3)9.9 (6.8)
 Missing897 (0.4)896 135 (22.3)510 (0.3)1 530 945 (39.6)
Total cholesterol: high-density lipoprotein cholesterol ratio (mmol/L), mean (SD)3.9 (1.0)3.7 (1.2)4.6 (1.2)4.4 (1.4)
 Missing35 880 (15.4)2 421 398 (60.2)22 694 (13.3)2 402 100 (62)
Family history of coronary heart disease99 896 (42.8)481 628 (12.0)61 453 (36.1)357 987 (9.3)
Self-reported ethnicity
 White or not stated221 300 (94.9)3 564 651 (88.7)161 300 (94.8)3 435 408 (88.8)
 Indian2255 (1.0)77 683 (1.9)1929 (1.1)81 805 (2.1)
 Pakistani538 (0.2)39 541 (1.0)703 (0.4)46 948 (1.2)
 Bangladeshi46 (<0.1)31 930 (0.8)94 (0.1)42 111 (1.1)
 Other Asian670 (0.3)53 559 (1.3)638 (0.4)45 753 (1.2)
 Black Caribbean2337 (1.0)37 781 (0.9)1293 (0.8)30 610 (0.8)
 Black African1380 (0.6)77 813 (1.9)1325 (0.8)71 245 (1.8)
 Chinese879 (0.4)33 767 (0.8)486 (0.3)23 730 (0.6)
 Other ethnic group3828 (1.6)103 231 (2.6)2369 (1.4)92 237 (2.4)
Townsend deprivation score, mean (SD)−1.4 (3.0)0.4 (3.2)−1.3 (3.1)0.5 (3.3)
Body mass index (kg/m2), mean (SD)26.7 (5.0)25.4 (5.1)27.4 (4.02)25.9 (4.2)
 Missing1148 (0.5)1 093 554 (27.2)1098 (0.6)1 393 672 (36.0)
Smoking status
 Non-smoker140 470 (60.2)2 051 803 (51.0)88 708 (52.1)1 463 941 (37.8)
 Ex-smoker71 274 (30.6)589 521 (14.7)59 143 (34.8)594 265 (15.4)
 Light smoker (<10 a day)2743 (1.2)434 954 (10.8)1656 (1.0)507 523 (13.1)
 Moderate smoker (10–19 a day)7765 (3.3)226 128 (5.6)5705 (3.4)251 170 (6.5)
 Heavy smoker (20 or over a day)4693 (2.0)115 890 (2.9)5927 (3.5)188 857 (4.9)
 Missing6288 (2.7)601 660 (15.0)8998 (5.3)864 091 (22.3)
Atrial fibrillation669 (0.3)15 177 (0.4)1190 (0.7)20 098 (0.5)
Erectile dysfunctionNANA698 (0.4)90 753 (2.3)
Migraine10 421 (4.5)257 825 (6.4)2613 (1.5)103 995 (2.7)
Rheumatoid arthritis3239 (1.4)45 700 (1.1)1171 (0.7)20 997 (0.5)
Chronic kidney disease227 (0.1)19 396 (0.5)189 (0.1)12 254 (0.3)
Severe mental illness1013 (0.4)274 069 (6.8)881 (0.5)167 115 (4.3)
Systemic lupus erythematosus440 (0.2)4010 (0.1)45 (<0.1)365 (<0.1)
Diabetes type 117 (<0.1)10 060 (0.3)16 (<0.1)11 617 (0.3)
Diabetes type 21797 (0.8)48 022 (1.2)2161 (1.3)58 395 (1.5)
Second-generation ‘atypical’ antipsychotic use483 (0.2)19 140 (0.5)456 (0.3)20 123 (0.5)
Corticosteroid use1898 (0.8)96 955 (2.4)1253 (0.7)56 533 (1.5)
Treated hypertension29 089 (12.5)223 494 (5.6)19 167 (11.3)164 255 (4.2)
  • Values are number (percentages) unless otherwise stated.