Univariate and multivariate Cox regression analyses for all-cause mortality and composite events in the external validation cohort (RAFFINE registry)
| Variable | Univariate analysis | Multivariate analysis (model 1) | Multivariate analysis (model 2) | |||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| All-cause mortality | ||||||
| Cluster 1 (ref) | – | – | – | – | – | – |
| Cluster 2 | 3.0 (1.5 to 5.8) | <0.001 | 2.3 (1. to 4.5) | 0.01 | 2.2 (1.1 to 4.5) | 0.02 |
| Cluster 3 | 3.7 (1.9 to 7.3) | <0.001 | 3.0 (1.5 to 6.1) | 0.001 | 3.0 (1.4 to 6.1) | 0.002 |
| Cluster 4 | 7.2 (3.7 to 13.9) | <0.001 | 4.3 (2.0 to 9.7) | <0.001 | 7.8 (3.6 to 16.7) | <0.001 |
| Cluster 5 | 8.1 (4.2 to 15.4) | <0.001 | 4.5 (2.1 to 9.7) | <0.001 | 5.1 (2.5 to 10.4) | <0.001 |
| Composite events | ||||||
| Cluster 1 (ref) | – | – | – | – | – | – |
| Cluster 2 | 3.4 (2.0 to 6.0) | <0.001 | 2.9 (1.6 to 5.1) | <0.001 | 2.7 (1.5 to 4.9) | <0.001 |
| Cluster 3 | 4.8 (2.7 to 8.5) | <0.001 | 4.2 (2.4 to 7.5) | <0.001 | 3.8 (2.1 to 7.0) | <0.001 |
| Cluster 4 | 7.2 (4.1 to 12.5) | <0.001 | 5.0 (2.7 to 9.4) | <0.001 | 5.8 (3.1 to 10.9) | <0.001 |
| Cluster 5 | 12.2 (7.1 to 21.0) | <0.001 | 8.3 (4.5 to 15.4) | <0.001 | 8.2 (4.6 to 14.5) | <0.001 |
Model 1: adjusted for CHA2DS2-VASc score; model 2: adjusted for age ≥75 years, sex and type of atrial fibrillation.
CHA2DS2-VASc, congestive heart failure, hypertension, age ≥75 years, diabetes, stroke, vascular disease, age 65–74 years and male; RAFFINE, Registry of Japanese Patients with Atrial Fibrillation Focused on anticoagulant therapy in New Era; ref, reference.