Univariate and multivariate Cox regression analyses for all-cause mortality and composite events in the derivation cohort (SAKURA AF registry)
| Variable | Univariate analysis | Multivariate analysis (model 1) | Multivariate analysis (model 2) | |||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| All-cause mortality | ||||||
| Cluster 1 (ref) | – | – | – | – | – | – |
| Cluster 2 | 8.4 (2.0 to 35.0) | 0.003 | 5.4 (1.2 to 22.8) | 0.02 | 5.7 (1.3 to 24.0) | 0.01 |
| Cluster 3 | 17.4 (4.2 to 72.0) | <0.001 | 13.1 (3.1 to 54.8) | 0.02 | 11.7 (2.8 to 49.4) | <0.001 |
| Cluster 4 | 22.0 (5.1 to 90.2) | <0.001 | 9.2 (2.0 to 40.9) | 0.003 | 21.7 (4.9 to 95.0) | <0.001 |
| Cluster 5 | 18.2 (4.4 to 75.7) | <0.001 | 6.5 (1.4 to 30.3) | 0.01 | 10.1 (2.4 to 43.2) | 0.001 |
| Composite events | ||||||
| Cluster 1 (ref) | – | – | – | – | – | – |
| Cluster 2 | 4.2 (2.2 to 7.8) | <0.001 | 3.2 (1.7 to 6.2) | <0.001 | 3.4 (1.8 to 6.5) | <0.001 |
| Cluster 3 | 5.2 (2.7 to 9.9) | <0.001 | 4.4 (2.3 to 8.5) | <0.001 | 4.3 (2.2 to 8.3) | <0.001 |
| Cluster 4 | 6.3 (3.4 to 11.8) | <0.001 | 3.9 (1.9 to 7.9) | <0.001 | 7.3 (3.6 to 14.7) | <0.001 |
| Cluster 5 | 7.9 (4.2 to 14.7) | <0.001 | 4.4 (2.0 to 9.4) | <0.001 | 5.9 (3.1 to 1.4) | <0.001 |
Model 1: adjusted for CHA2DS2-VASCc score; model 2: adjusted for age ≥75 years, sex and type of atrial fibrillation.
CHA2DS2-VASCc, congestive heart failure, hypertension, age ≥75 years, diabetes, stroke, vascular disease, age 65–74 years and male; ref, reference; SAKURA AF, Real World Survey of Atrial Fibrillation Patients Treated with Warfarin and Non-vitamin K Antagonist Oral Anticoagulants.