Table 2

Proportion of patients with an outcome of interest during study follow-up

Patients with at least one CV event or death
N=1 42 787
n (%)
At least one outcome of interest, composite measure43 564 (30.5)
Type of CV event or death
Hospitalisation for acute coronary syndrome*5622 (3.9)
 Acute myocardial infarction4894 (3.4)
 Unstable angina943 (0.7)
Hospitalisation for heart failure decompensation*4485 (3.1)
 (Congestive) heart failure4201 (2.9)
 Acute pulmonary oedema321 (0.2)
Hospitalisation for cerebral ischaemia*3480 (2.4)
 Cerebral infarction2640 (1.8)
 Transient ischaemic attack (transient cerebral ischaemic attacks and related syndromes)941 (0.7)
Hospitalisation with a new diagnosis of arrhythmia*†3254 (2.3)
 Atrial fibrillation and flutter2538 (1.8)
 Other cardiac arrhythmias539 (0.4)
 Cardiac arrest283 (0.2)
Death during study follow-up*34 068 (23.9)
 COPD-related death‡4973 (3.5)
 CV-related death§10 132 (7.1)
 Multiple cause (COPD and CV) death81 (0.1)
 Death due to other or unknown causes18 882 (13.2)
  • *Patients with a first CV event of each type or death are counted; the sum of percentages for each type of event (or death) is greater than 100% due to some patients experiencing several types of outcomes.

  • †New diagnosis of atrial fibrillation defined as the absence of code I48 or I49 in the medical history of the patient prior to cohort entry date.

  • ‡COPD-related death was defined using reason codes or diagnosis codes of J41, J42, J43 or J44 from Vital Statistics or the Discharge Abstract Database (DAD).

  • §CV-related death was defined using International Classification of Diseases 10th Revision (ICD-10-CA) codes of I00-I99 from Vital Statistics or the Discharge Abstract Database (DAD).

  • COPD, chronic obstructive pulmonary disease; CV, cardiovascular.