Comparison of haemodynamic status and exercise tolerance before and after BPA in the low DLco and normal DLco groups
| Low DLco (n=36) | Normal DLco (n=39) | Normal vs low DLco (comparison of post-value*) | |||||||
| Baseline | Follow-up | Change | Baseline | Follow-up | Change | Standardised regression coefficient | 95% CI | P value | |
| Haemodynamics | |||||||||
| mean RAP, mm Hg | 6.2±3.0 | 6.5±3.0 | 0.3 (0.6) | 6.6±2.9 | 5.4±1.9 | −1.2 (0.6) | −0.233 | (−2.374 to −0.023) | 0.046 |
| mean PAP, mm Hg | 38.9±7.3 | 25.1±7.4 | −13.9 (1.5) | 41.1±9.2 | 21.5±5.6 | −19.7 (1.5) | −0.304 | (−7.015 to −1.132) | 0.007 |
| Cardiac output, L/min | 4.7±1.6 | 4.7±1.2 | 0.0 (0.2) | 4.2±0.9 | 4.7±1.3 | 0.47 (0.2) | 0.109 | (−0.232 to 0.768) | 0.288 |
| PVR, dyn·s/cm-5 | 589.1±290.1 | 282.1±159.4 | −306.9 (42.4) | 625.8±197.9 | 203.2±84.6 | −423.0 (34.6) | −0.324 | (−141.0 to 29.81) | 0.003 |
| SaO2, % | 89.1 (86.8–92.5) | 94.9 (91.2–96.0) | 4.2 (0.9) | 92.6 (91.0–94.7) | 96.4 (95.5–97.0) | 3.7 (0.5) | 0.261 | (0.294 to 3.351) | 0.020 |
| SvO2, % | 61.9 (57.3–68.6) | 70.3 (67.1–73.4) | 6.9 (1.6) | 67.3 (62.4–70.3) | 74.0 (69.9–75.8) | 7.8 (1.2) | 0.247 | (0.344 to 6.057) | 0.029 |
| 6-minute walk distance, m | 324±91 (n=32) | 409±96 (n=34) | 86 (14) (n=32) | 427±114 (n=37) | 489±95 (n=35) | 66 (13) (n=34) | 0.076 | (−22.43 to 53.89) | 0.413 |
Values are presented as the mean±SD, median (IQR) or mean (SE).
*Based on the analysis of covariance adjusted for baseline value.
BPA, balloon pulmonary angioplasty; DLco, diffusing capacity of the lungs for carbon monoxide; PAP, pulmonary artery pressure; PVR, pulmonary vascular resistance; RAP, right atrial pressure; SaO2, arterial oxygen saturation; SvO2, mixed venous oxygen saturation.