Table 2

Overview of aortic diameters and growth rates pre-trial and during the trial period in patients enrolled in the RESVcue study

n=57	Diameter (mm) Mean±SE			Estimated annual growth rate (mm/year) Mean±SE		P value adj†
Aortic level	Pre-trial	Baseline	Follow-up	Pre-trial	During trial	P value adj†
Root (n=31)	40.3±0.9	41.6±0.8*	41.4±0.8	0.39±0.06	−0.13±0.23	0.072
Ascending	29.0±0.4	30.7±0.4*	30.7±0.4	0.40±0.05	−0.01±0.18	0.072
Arch	25.2±0.4	26.6±0.4*	26.8±0.4	0.29±0.06	0.15±0.21	0.523
Proximal descending	25.9±0.6	26.7±0.6*	26.6±0.6	0.21±0.06	0.07±0.21	0.523
Distal descending	20.8±0.4	22.0±0.3*	22.0±0.3	0.32±0.04	0.01±0.14	0.072

For root diameter analysis, only patients with a native aortic root were analysed. Aortic growth rates and differences in aortic growth rates were estimated using a linear mixed model, correcting for differences in follow-up duration with a random intercept on the subject level .
*P value <0.05 after adjustment for multiple testing using the Benjamini-Hochberg procedure comparing pre-trial and baseline diameter.
†P value after adjustment for multiple testing using the Benjamini-Hochberg procedure.