Medicare claims and meal payments for sacubitril/valsartan from 2015 to 2021
| Variables | Sacubitril/valsartan | Angiotensin receptor blockers | Angiotensin-converting enzyme inhibitors |
| Medicare claims | |||
| Total amounts of Medicare spending during 2015–2021, US$ | 2 841 532 185 | 3 427 830 502 | 2 131 206 105 |
| Total number of 30-day standardised Medicare claims including refills during 2015–2021, n | 5 545 902 | 318 045 814 | 451 465 688 |
| Number of physicians who prescribed sacubitril/valsartan during 2015–2021, n (%) | 30 493 (13.9) | 187 258 (85.1) | 215 201 (97.8) |
| Mean Medicare spending per claim (SD), US$ | 492 (96) | 10 (12) | 5 (5) |
| Median annual Medicare claims per physician (IQR) | |||
| Medicare spending, US$ | 18 653 (9872–40 553) | 1636 (523–4045) | 1118 (325–2603) |
| Number of Medicare claims, n | 38 (22–80) | 216 (86–437) | 271 (87–582) |
| Meal payments for sacubitril/valsartan | |||
| Total payment amounts during 2015–2021 | |||
| Monetary amounts, US$ | 13 923 873 | – | – |
| Number of payments, n | 661 793 | – | – |
| Median payment value per payment (IQR), US$ | 17 (15–22) | – | – |
| Number of physicians who received meal payments during 2015–2021, n (%) | 60 568 (27.5) | – | – |
| Median annual payments per physician (IQR) | |||
| Monetary amounts, US$ | 41 (20–107) | – | – |
| Number of payments, n | 2 (1–4) | – | – |