Atherosclerotic distribution and plaque burden when stratified according to final clinical diagnosis and diagnostic guidewire result
| Characteristic | MVA (n=78) | VSA (n=25) | Mixed MVA and VSA (n=31) | Non-cardiac symptoms (n=17) | P value |
| Number of diseased coronary segments | 4 (2–7) | 4 (1–6) | 6 (3–8) | 3 (1–5) | 0.032 |
| Number of diseased proximal segments | 1 (1–3) | 1 (1–2) | 2 (1–2) | 1 (0–2) | 0.020 |
| Abnormal CFR/IMR (n=83) | Normal CFR/IMR (n=68) | ||||
| Number of diseased coronary segments | 5 (2–7) | 4 (1–6) | 0.039 | ||
| Number of diseased proximal segments | 2 (1–3) | 1 (0–2) | 0.022 | ||
| Gensini score | 7.5 (3.5–11.5) | 5.5 (2.5–10.0) | 0.028 | ||
CFR <2.0 or IMR ≥25 is considered abnormal. INOCA endotypes were defined according to the COVADIS criteria. The proximal coronary segments are the left main stem (LMS), proximal left anterior descending (LAD), proximal left circumflex (LCx) or proximal right coronary artery (RCA). All values are reported as median (IQR).
CFR, coronary flow reserve; COVADIS, Coronary Vasomotion Disorders International Study Group; IMR, Index of Microcirculatory Resistance; INOCA, ischaemia with no obstructive coronary artery disease; MVA, microvascular angina; VSA, vasospastic angina.