Summary of trials of exercise training in patients with chronic heart failure
| Year | n | Age | LVEF | PeakV˙o2 | Study design | |
|---|---|---|---|---|---|---|
| Uncontrolled | ||||||
| Sullivan5 | 1988 | 12 | 54.0 (10.0) | 24.0 (10.0) | 16.8 (3.8) | Open, no control |
| Minotti6 | 1990 | 5 | 60.0 (9.0) | 27.0 (7.6) | 15.5 (4.5) | Open, no control |
| Mancini7 | 1995 | 14 | 55.0 (14.0) | 22.0 (9.0) | 13.5 (4.8) | Unblinded, uncontrolled, control by drop out |
| Hornig8 | 1996 | 11 | 47.0 (5.0) | 21.0 (2.0) | 17.0 (2.0) | Open, control by normals |
| Magnusson9 | 1996 | 11 | 56.0 (9.0) | 19.8 (11.3) | 15.1 (2.9) | Open |
| Controlled | ||||||
| Meyer10 | 1991 | 12 | 63.0 (2.6) | 23.0 (3.2) | 13.0 (0.8) | Plecebo controlled crossover; lisinopril/placebo with/without training |
| Coats11 12 | 1992 | 17 | 61.8 (1.5) | 19.6 (2.3) | 13.2 (0.9) | Controlled crossover |
| Davey13 | 1992 | 22 | 64 (54–74) | 22.0 (8.0) | 14.1 (2.8) | Controlled crossover |
| Koch14 | 1992 | 25 | 55.0 (10.0) | 26.0 (10.0) | 18.9 (7.0) | Controlled open |
| Adamopoulos15 | 1993 | 12 | 62.4 (2.6) | 24.0 (3.4) | 12.1 (1.2) | Controlled crossover |
| Belardinelli16 | 1995 | 55 | 55.0 (7.0) | 27.0 (7.0) | 15.6 (1.3) | Controlled |
| Piepoli17 | 1996 | 12 | 59.6 (1.7) | 26.4 (1.6) | 14.6 (1.4) | Controlled crossover |
Values are mean (SD).
LVEF, left ventricular ejection fraction; peakV˙o 2, peak oxygen uptake.