Change from baseline for patients with post-baseline laboratory results (n=660)
| Variable | Baseline | Month 30 | Arithmetic change from baseline | % Change from baseline | ||||||
| Rimonabant (n=325) | Placebo (n=335) | Rimonabant (n=325) | Placebo (n=335) | Rimonabant (n=325) | Placebo (n=335) | p Value for change | Rimonabant (n=325) | Placebo (n=335) | p Value for % change | |
| BMI (kg/m2) | 33.7 (5.3) | 34.1 (6.0) | 32.0 (5.3) | 33.5 (5.9) | −1.7 (2.4) | −0.5 (2.2) | <0.0001 | −4.9 (6.4) | −1.4 (6.0) | <0.0001 |
| Waist circumference (cm) | 111.5 (11.8) | 112.4 (12.2) | 106.6 (12.5) | 110.4 (12.0) | −4.9 (6.7) | −2.0 (6.6) | <0.0001 | −4.4 (5.9) | −1.6 (5.6) | <0.0001 |
| SBP (mm Hg) | 140.8 (16.3) | 138.7 (16.5) | 138.4 (18.2) | 138.6 (17.4) | −2.3 (17.5) | −0.1 (16.6) | 0.29 | −1.1 (12.2) | 0.5 (12.2) | 0.26 |
| DBP (mm Hg) | 82.0 (9.5) | 81.2 (10.3) | 78.9 (10.1) | 79.0 (10.7) | −3.1 (10.4) | −2.2 (10.3) | 0.48 | −3.0 (13.3) | −2.0 (12.8) | 0.54 |
| Weight (kg) | 96.7 (17.3) | 97.6 (17.7) | 91.9 (17.2) | 96.1 (17.6) | −4.8 (6.7) | −1.6 (6.4) | <0.0001 | −4.9 (6.4) | −1.4 (6.0) | <0.0001 |
| HDL-c (mg/dl) | 49.3 (11.3) | 50.0 (12.8) | 49.3 (12.6) | 46.7 (13.0) | 0.07 (8.4) | −3.3 (7.6) | <0.0001 | 1.0 (17.1) | −5.8 (15.2) | <0.0001 |
| LDL-c (mg/dl) | 111.5 (39.7) | 111.6 (42.3) | 111.0 (36.9) | 111.8 (42.8) | −0.6 (33.3) | 0.2 (34.0) | 0.73 | −6.5 (37.4) | 7.7 (52.4) | 0.70 |
| Triglycerides (mg/dl)* | 169.2 (118.7; 237.4) | 175.4 (135.5; 241.8) | 144.4 (105.4; 208.1) | 153.2 (123.1; 217.9) | −19.5 (−63.8; 15.9) | −14.2 (−61.1; 21.3) | 0.24 | −15.1 (−33.5; 11.0) | −9.3 (−30.6; 14.9) | 0.13 |
| hs-CRP (mg/l)* | 2.44 (1.30; 4.70) | 2.60 (1.40; 5.32) | 2.00 (1.06; 4.00) | 2.50 (1.36; 4.60) | −0.31 (−1.50; 0.50) | −0.02 (−1.15; 0.90) | 0.03 | −18.8 (−48.4; 29.4) | −0.9 (−37.9; 45.0) | 0.01 |
| HbA1c (%) | 6.3 (0.9) | 6.3 (0.9) | 6.2 (0.9) | 6.3 (0.9) | −0.1 (0.7) | −0.04 (0.6) | 0.08 | −1.7 (9.0) | −0.2 (9.2) | 0.05 |
| Glucose (mg/dl) | 122.8 (35.6) | 121.6 (34.2) | 121.1 (31.5) | 119.9 (36.0) | −1.7 (28.2) | −1.7 (33.8) | 0.81 | 0.9 (18.0) | 0.9 (24.1) | 0.87 |
Unless otherwise stated, values are mean (SD). p Values are from an analysis of covariance model with treatment as a factor and baseline values as a covariate.
↵* Results reported as median (Q1, Q3).
BMI, body mass index; DBP, diastolic blood pressure; HbA1c, glycosylated haemoglobin; HDL-c, high-density lipoprotein cholesterol; hs-CRP, high-sensitivity C-reactive protein; LDL-c, low-density lipoprotein cholesterol; SBP, systolic blood pressure.