Table 1

Number of index cases and relatives identified by the four cascade strategies

Outcome	Cascade strategies
	Cholesterol	DNA	DNA+DFH	DNA+DFH+PFH
Cases (N=1000)
True positive	480^*	420^*	450^*	480^*
False negative	0	60	30^*	0
False positive	420^*	420	420	420^*
True negative	100	100	100	100
Relatives
True positive	765	1338	1385	1433
False negative	430	0	27	53
False positive	497	0	33	297
True negative	2611	1338	1513	2898
Total relatives tested	4302	2675	2959	4681

↵* Probands where cascade testing was undertaken.
DFH, definite familial hypercholesterolaemia; PFH, possible familial hypercholesterolaemia.