Supine measurements and haemodynamic changes during GTN-HUT at the end of pretreatment (baseline), placebo, and midodrine study periods
| Study period | Heart rate (beats/min) | Change in heart rate | SBP (mm Hg) | Change in SBP | DBP (mm Hg) | Time (mins) |
|---|---|---|---|---|---|---|
| Steady state before tilt (n = 16) | ||||||
| Baseline | 74.6 (8) | 127.0 (18) | 66.7 (9) | |||
| Placebo | 75.5 (9) | 124.4 (20) | 66.2 (11) | |||
| Midodrine | 69.8 (9)1-150 | 141.4 (26)1-150 | 70.4 (13) | |||
| At the time of symptoms during tilt (positive responders only) | ||||||
| Baseline (n = 16) | 68 (10) | −7 (11) | 66 (25) | −71 (24) | 6.4 (2) | |
| Placebo (n = 14) | 71 (11) | −9 (8) | 65 (22) | −69 (19) | 6.3 (3) | |
| Midodrine (n = 6 ) | 68 (15) | −6 (12) | 71 (16) | −73 (18) | 8.8 (2) | |
Values are mean (SD).
↵1-150 p < 0.05.
SBP, systolic blood pressure; DBP, diastolic blood pressure.