Table 5

Doppler findings in Friedreich’s ataxia

GAA expansion (n=45)Normal allele (n=10)p Value
Aortic studies
Peak velocity (m/s)1.1 (0.2)1.3 (0.2)0.04
Velocity integral (cm2)0.19 (0.03)0.25 (0.06)0.02
Maximum acceleration (m s−2)1.1 (0.2)1.3 (0.2)0.01
Ejection time (ms)270 (24)305 (30)0.02
Left ventricular outflow tract studies
Peak velocity (m/s)3.8 (1.4)5.1 (2.2)0.02
Velocity integral (cm2)0.2 (0.03)0.2 (0.06)0.04
Transmitral ventricular filling
Velocity–time integral (cm2)0.18 (0.03)0.21 (0.05)0.01
Pressure half time (ms)60 (15)66 (17)NS
Deceleration time (ms)205 (50)226 (28)NS
Peak E wave velocity (m s−2)0.76 (0.11)0.81 (0.15)NS
Peak A wave velocity (m s−2)0.49 (0.13)0.69 (0.10)0.05
E/A ratio1.67 (0.77)1.23 (0.30)0.05
Isovolumetric relaxation time (ms)76 (16)78 (9)NS
  • Values are mean (SD).