Doppler findings in Friedreich’s ataxia
| GAA expansion (n=45) | Normal allele (n=10) | p Value | |
|---|---|---|---|
| Aortic studies | |||
| Peak velocity (m/s) | 1.1 (0.2) | 1.3 (0.2) | 0.04 |
| Velocity integral (cm2) | 0.19 (0.03) | 0.25 (0.06) | 0.02 |
| Maximum acceleration (m s−2) | 1.1 (0.2) | 1.3 (0.2) | 0.01 |
| Ejection time (ms) | 270 (24) | 305 (30) | 0.02 |
| Left ventricular outflow tract studies | |||
| Peak velocity (m/s) | 3.8 (1.4) | 5.1 (2.2) | 0.02 |
| Velocity integral (cm2) | 0.2 (0.03) | 0.2 (0.06) | 0.04 |
| Transmitral ventricular filling | |||
| Velocity–time integral (cm2) | 0.18 (0.03) | 0.21 (0.05) | 0.01 |
| Pressure half time (ms) | 60 (15) | 66 (17) | NS |
| Deceleration time (ms) | 205 (50) | 226 (28) | NS |
| Peak E wave velocity (m s−2) | 0.76 (0.11) | 0.81 (0.15) | NS |
| Peak A wave velocity (m s−2) | 0.49 (0.13) | 0.69 (0.10) | 0.05 |
| E/A ratio | 1.67 (0.77) | 1.23 (0.30) | 0.05 |
| Isovolumetric relaxation time (ms) | 76 (16) | 78 (9) | NS |
Values are mean (SD).