Haemodynamic variables and neurohormonal measurements at baseline
| No dilatation (n = 43) | Limited dilatation (n = 11) | Progressive dilatation (n = 11) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Rest | Exercise | Rest | Exercise | Rest | Exercise | ||||||
| Heart rate (beats/min) | 69 (3) | 109 (4)) | 61 (4) | 113 (7) | 72 (4) | 111 (7) | |||||
| MAP (mm Hg) | 97 (2) | 104 (2) | 99 (4) | 107 (5) | 99 (3) | 112 (6) | |||||
| Cardiac index (l/min/m2) | 2.35 (0.1) | 6.5 (0.3) | 2.46 (0.2) | 6.68 (0.7) | 2.22 (0.2) | 5.49 (0.4) | |||||
| SVI (ml/m2) | 36.6 (2) | 65.9 (2.8) | 43 (3.9) | 72.4 (7.9) | 32.3 (3.2) | 52.3 (4.9) | |||||
| Oxygen uptake (ml/min/kg) | 4.2 (0.2) | 17.6 (0.6) | 3.87 (0.2) | 16.9 (2.1) | 4.26 (0.3) | 14.2 (0.8) | |||||
| SVR (dyn.cm-5) | 1802 (67) | 737 (40) | 1721 (143) | 706 (75) | 2029 (179) | 949 (102) | |||||
| ANF (pg/ml) | 3.9 (0.1) | 4.7 (0.1) | 4.37 (0.1) | 5.3 (0.2) | 4.15 (0.1) | 5 (0.3) | |||||
| 49 | 110 | 81 | 200 | 67 | 148 | ||||||
| Noradrenaline (pg/ml) | 6.6 (0.1) | 7.2 (0.1) | 6.5 (0.1) | 7.2 (0.2) | 6.44 (0.1) | 7.1 (0.1) | |||||
| 735 | 1339 | 665 | 1339 | 601 | 1211 | ||||||
| Adrenaline (pg/ml) | 4.26 (0.1) | 4.9 (0.1) | 4.53 (0.2) | 5.2 (0.2) | 4.04 (0.3) | 4.5 (0.2) | |||||
| 74 | 134 | 90 | 185 | 55 | 90 | ||||||
| Renin (ng/ml/h Ang I) | −0.03 (0.2) | 0.28 (0.2) | −0.57 (0.3) | 0.04 (0.3) | 0.03 (0.3) | 0.3 (0.4) | |||||
| 0.97 | 1.3 | 0.57 | 1.04 | 1.03 | 1.34 | ||||||
Values are mean (SEM) (haemodynamics) and log mean (SEM) (neurohormones). Geometric neurohormonal mean values are shown in bold.
ANF, atrial natriuretic factor; Ang, angiotensin; MAP, mean arterial pressure; SVI, stroke volume index; SVR, systemic vascular resistance.