Table 3

Cardiovascular risk factors and adjusted relative risk of major CHD events by specific period of follow up in men with no diagnosed CHD with available data on all lifestyle covariates

		Specific period of follow up (years)
		0–5.0	5.1–10	10.1–15
Number of events/subjects	224/7198	284/6838^3-154	291/6319^3-154
Rates/1000 person-years	6.4	8.7	9.6
Lifestyle and pre-existing disease^3-151
Smoking (v never)
Ex	1.9	1.1 (0.7 to 1.5)	1.7 (1.2 to 2.6)^**
Current	2.9	1.6 (1.2 to 2.2)^**	3.0 (2.1 to 4.3)^***
BMI (⩾ 28v < 22 kg/m²)	1.4	1.7 (1.1 to 2.7)^**	2.3 (1.4 to 3.7)^***
Alcohol (light/moderatev occasional)	0.9	0.7 (0.6 to 1.0)^*	0.7 (0.5 to 0.9)^*
Physical activity (moderatev none)	0.6	0.5 (0.3 to 0.8)^**	0.5 (0.3 to 0.9)^**
Parental history (yes/no)	1.5	1.6 (1.3 to 2.0)^***	1.5 (1.1 to 1.9)^***
Pre-existing CHD (no diagnosis)	1.8	1.6 (1.3 to 2.1)^***	1.3 (1.0 to 1.7)^*
Diabetes (yes/no)	1.9	2.8 (1.6 to 5.2)^***	1.7 (0.7 to 3.8)
Biological factors^3-152
Systolic blood pressure^3-153	3.0	1.8 (1.2 to 2.6)^**	1.5 (1.0,2.1)⁺
Diastolic blood pressure^3-153	2.0	1.7 (1.2 to 2.6)^**	1.7 (1.2 to 2.5)^*
Cholesterol^3-153	2.3	2.6 (1.8 to 3.7)^***	2.7 (1.9 to 3.9)^***
HDL cholesterol^3-153	0.6	0.5 (0.4 to 0.8)^***	0.5 (0.4 to 0.8)^**
Glucose (⩾ 6.2 mmol/l vrest)	1.1	1.4 (1.0 to 1.8)^*	1.0 (0.7 to 1.3)
Insulin (top decile v rest)	2.2	1.3 (0.9 to 1.9)	1.4 (0.9 to 2.1)

Test for difference/trend: ⁺p = 0.05; ^*p < 0.05;^**p < 0.01; ^***p < 0.001.
↵3-151 Adjusted for age, lifestyle factors, diabetes, and pre-existing CHD.
↵3-152 Adjustments made in addition for systolic blood pressure and total cholesterol.
↵3-153 Top quartile v bottom quartile.
↵3-154 Men who died or developed major CHD before the specific follow up period were excluded.