Comparison of patient characteristics in relation to values of plasma adrenomedullin above and below the median value (10.3 pmol/l)
| Low AM group (n = 57) | High AM group (n = 56) | p Value | |
|---|---|---|---|
| Demographics | |||
| Cardiovascular deaths (n) | 3 | 13 | < 0.01 |
| Age (years) | 60 (11) | 64 (12) | NS |
| Male sex (n) | 43 | 43 | NS |
| Clinical variables | |||
| Anterior MI (n) | 22 | 39 | < 0.01 |
| Previous MI (n) | 5 | 8 | NS |
| Successful reperfusion (n) | 51 | 46 | NS |
| Killip II, III, IV (n) | 12 | 22 | < 0.05 |
| Previous angina (n) | 34 | 37 | NS |
| Maximum CK (U/l) | 3526 (3539) | 4368 (3398) | NS |
| Hypertension (n) | 29 | 32 | NS |
| Haemodynamic data on admission (n = 108) | (n = 55) | (n = 53) | |
| Heart rate (beats/min) | 79 (17) | 82 (18) | NS |
| SBP (mm Hg) | 127 (20) | 128 (25) | NS |
| PCWP (mm Hg) | 13 (6) | 15 (7) | NS |
| RAP (mm Hg) | 7 (4) | 7 (5) | NS |
| mPAP (mm Hg) | 20 (6) | 21 (8) | NS |
| Cardiac index (l/min/m2) | 3.0 (0.9) | 2.6 (0.7) | < 0.05 |
| LVEF on admission (%) | 49 (10) | 39 (10) | < 0.001 |
| Drugs on discharge | |||
| ACE inhibitor (n) | 13 | 22 | NS |
| Diuretics (n) | 4 | 14 | < 0.01 |
| Calcium antagonist (n) | 40 | 39 | NS |
| Nitrate (n) | 39 | 36 | NS |
| β Blocker (n) | 4 | 4 | NS |
| Plasma AM on day 2 (pmol/l) | 7.3 (2.2) | 17.4 (10.1) | < 0.001 |
Values are means (SD) unless otherwise stated.
ACE, angiotensin converting enzyme; AM, adrenomedullin; CK, creatine kinase; Killip, Killip heart failure classification; LVEF, left ventricular ejection fraction; MI, myocardial infarction; mPAP, mean pulmonary arterial pressure; PCWP, pulmonary capillary wedge pressure; RAP, mean right atrial pressure; SBP, systolic blood pressure.