Reactivity of proximal and distal segments and coronary stenoses to substance (sub) P before and afterl-arginine infusion
| Saline | Sub P1 (5.6 pmol) | Sub P1 (27.8 pmol) | l-arginine (150 μmol) | Sub P2 (5.6 pmol) | Sub P2 (27.8pmol) | |
|---|---|---|---|---|---|---|
| Coronary artery disease | ||||||
| Proximal (n = 23) | 3.08 (0.13) | 3.28 (0.14) | 3.29 (0.12) | 3.27 (0.13) | 3.34 (0.15) | 3.39 (0.13)2-151 |
| (0.6 (0.3)%) | (7.1 (1.5)%) | (8.6 (1.7)%) | (8.5 (1.1)%) | (8.4 (1.5)%) | (12.7 (1.8)%) | |
| Distal (n = 26) | 1.43 (0.05) | 1.60 (0.06)2-150 | 1.61 (0.07)2-150 | 1.50 (0.07) | 1.65 (0.07)** | 1.70 (0.07)2-151 |
| (0.7 (0.5)%) | (14.2 (2.5)%) | (15.3 (2.3)%) | (6.7 (1.3)%) | (15.7 (2.1)%) | (21.8 (2.8)%) | |
| Stenoses (n = 14) | 1.48 (0.14) | 1.64 (0.16) | 1.72 (0.19) | 1.70 (0.18) | 1.82 (0.16)2-151 | 1.84 (0.19)2-151 |
| (0.8 (0.6)%) | (10.9 (2.5)%) | (11.8 (3.3)%) | (11.7 (2.3)%) | (18.3 (2.8)%) | (20.3 (2.7)%) | |
| Normal coronary arteries | ||||||
| Proximal (n = 9) | 3.05 (0.27) | 3.25 (0.25) | 3.40 (0.23) | 3.20 (0.28) | 3.35 (0.24)†† | 3.49 (0.24) |
| (0.9 (0.5)%) | (8.6 (3.6)%) | (14.4 (4.3)%) | (10.4 (3.4)%) | (12.4 (3.7)%) | (17.4 (4.1)%) | |
| Distal (n = 14) | 1.50 (0.04) | 1.68 (0.07)2-150 | 1.71 (0.05) | 1.55 (0.06) | 1.69 (0.01) | 1.79 (0.06)†† |
| (0.6 (0.7)%) | (13.4 (4.0)%) | (15.5 (2.3)%) | (6.5 (2.9)%) | (14.6 (3.8)%) | (20.6 (2.9)%) | |
Values are mean (SEM) luminal diameter in mm (mean (SEM) percentage change from baseline).
p < 0.01 all responses to substance P vnormal saline in both groups.
↵2-150 p < 0.05, **p < 0.01 v proximal segments.
↵2-151 p < 0.01, ††p < 0.05 v the pre-l-arginine responses.
1 = before l-arginine administration; 2 = afterl-arginine administration; CA, coronary arteries.