Changes in plasma angiotensin II, aldosterone, and urinary sodium concentration with and without ACE inhibition
| Placebo | ACE inhibitor | Changes | |
| Angiotensin II (pmol/l) | |||
| Low PRA | 7.5 (4.8) | 4.3 (3.2) | 3.2 (3.7) (95% CI 0.8 to 5.7); p = 0.015 |
| Normal PRA | 11.4 (7.7) | 2.74 (2.3) | 8.7 (7.0) (95% CI 4.5 to 12.9); p = 0.001 |
| High PRA | 49.0 (46.4) | 3.8 (3.3) | 45.2 (45.8) (95% CI 17.5 to 72.8); p = 0.004 |
| 2-150p < 0.001 | p = 0.419 | ||
| Aldosterone (pmol/l) | |||
| Low PRA | 262 (146) | 219 (158) | 42 (88) (95% CI −16 to 102); p = 0.138 |
| Normal PRA | 336 (172) | 234 (235) | 102 (167) (95% CI 2 to 203); p = 0.047 |
| High PRA | 599 (312) | 260 (118) | 338 (281) (95% CI 149 to 527); p = 0.003 |
| 2-150p < 0.001 | p = 0.948 | ||
| Urine sodium (mmol/l) | |||
| Low PRA | 96.7 (39.5) | 101.8 (33.6) | −5.1 (23.6) (95% CI −21.0 to 10.8); p = 0.491 |
| Normal PRA | 90.4 (26.7) | 94.5 (33.1) | −4.1 (24.0) (95% CI −18.6 to 10.4); p = 0.551 |
| High PRA | 66.3 (18.9) | 80.8 (22.5) | −14.6 (21.3) (95% CI −27.4 to −1.73); p = 0.02 |
| 2-150p = 0.033 | p = 0.231 | ||
↵2-150 Post hoc pairwise comparisons suggested that the plasma angiotensin II and aldosterone levels were not different between the low and normal PRA groups, but the levels of these hormones were significantly higher in the high PRA groups than in either low or normal PRA groups.
ACE, angiotensin converting enzyme; PRA, plasma renin activity.