Summary of direct comparisons of cTnT with cTnI in risk stratification in acute coronary syndromes
| Study | Study population | cTnT (cut off) | cTnI (cut off) | Positive cTnT (patients) | Positive cTnI (patients) | Follow up | Death/AMI in cTnT positive patients | Death/AMI in cTnI positive patients |
| Hamm et al
6
(n = 315) | Any age, ⩽ 12 h chest pain, no ST elevation, no AMI within 14 days | Bedside (0.18 ng/ml) | Bedside (0.1 ng/ml) | 70 (22%) | 114 (36%) | 30 days | 22% | 19% |
| TRIM3
(n = 516) | 25–80 years, < 24 h chest pain, ST depression , T wave inversion or proven IHD | ES 300 (0.1 μg/l) | Opus Magnum (2.0 μg/l) | 249 (48%) | 213 (41%) | 30 days | 11% | 11% |
| FRISC I13
(n = 823) | > 40 years, < 72 h chest pain, ST depression or T wave inversion | Enzymun (0.1 μg/l) | Access (0.1 μg/l) | 66% | 5 months | 16.7% | 17.3% | |
| GUSTO IIa14 (n = 770) | Any age, < 12 h chest pain, ⩾ 0.05 mV ST depression or elevation, LBBB or T wave inversion | ES 300 (0.1 μg/l) | Stratus II (1.5 μg/l) | 278 (36%) | 220 (29%) | 30 days | 12% | 13% |
| Ottani et al
15
(n = 74) | Any age, < 48 h chest pain, > 0.05 mV ST elevation or depression, or T wave inversion | ES 300 (0.1 μg/l) | Baxter Stratus (3.1 μg/l) | 18 (24%) | 18 (24%) | 30 days | 17% | 28% |
AMI, acute myocardial infarction; IHD, ischaemic heart disease; LBBB, left bundle branch block.