Aetiology of heart failure in clinical trials and registers.11–17
| Clinical trials | Registers | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| SOLVD 1991 | DIG Study 1997 | MERIT-HF 1999 | ATLAS 1999 | RALES 1999 | SOLVD 1992 | SPICE 1999 | |||
| Size of cohort | 2569 | 6800 | 3991 | 3192 | 1663 | 6273 | 9580 | ||
| Mean age | 61 | 64 | 64 | 64 | 65 | 62 | 66 | ||
| Male (%) | 80 | 78 | 78 | 79 | 73 | 74 | 74 | ||
| Aetiology of heart failure | |||||||||
| Ischaemic | 71% | 70% | 66% | 64% | 54% | 69% | 63% | ||
| Non-ischaemic | – | 29% | 34% | 35% | 46% | 31% | – | ||
| Hypertensive | – | (9%) | – | (20%) | – | 7% | 4% | ||
| IDCM | 18% | (15%) | – | (28%) | – | 13% | 17% | ||
| Valvar | – | – | – | (6%) | – | – | 5% | ||
| Other | – | 6% | – | – | – | 11% | – | ||
| Unknown | – | – | – | – | – | 6% | |||
| Comorbidity | |||||||||
| Hypertension | 42% | – | 44% | 46% | – | 43% | 27% | ||
| Diabetes | 26% | – | 25% | 29% | – | 23% | – | ||
| Atrial fibrillation | 10% | – | 17% | – | – | 14% | – | ||
| Current angina | 37% | – | – | 27% | – | – | |||
| Respiratory disease | 26% | – | – | – | – | 15% | – | ||