|
Non-smokers
|
Ex-smokers
|
Current smokers
|
Significance level |
Number of patients | 728 | 1690 | 530 | |
Men | 65.3% | 87.5%1-150
| 85.9%1-150
|
0.000
|
Age (years) (mean (SD)) | 59.9 (9.4) | 57.0 (9.1)1-150
| 54.0 (9.0) |
0.000 |
Previous myocardial infarct | 37.9% | 43.9%1-150
| 42.9%1-150
|
0.022
|
Previous CABG | 3.6% | 4.6% | 4.0% | 0.470 |
Previous PTCA | 4.1% | 5.1% | 5.5% | 0.486 |
Diabetes mellitus | 12.6% | 9.5%1-150
| 9.1%1-150
|
0.043
|
IDDM | 1.8% | 0.7%1-150
| 0.4%1-150
|
0.009
|
History of hypertension | 37.2% | 29.3%1-150
| 24.9%1-150
|
0.000
|
History of hypercholesterolaemia | 32.0% | 31.5% | 31.9% | 0.965 |
History of PVD | 2.3% | 5.5%1-150
| 7.2%1-150
|
0.000
|
Anginal class
| | | | |
None | 6.3% | 5.8% | 4.3% | |
CCS class I | 9.8% | 11.7% | 11.3% | |
CCS class II | 34.6% | 32.6% | 29.4% | |
CCS class III | 31.5% | 29.9% | 29.1% | |
CCS class IV | 17.9% | 20.2% | 25.9%1-150
1-151
|
0.032
|
Duration of angina (weeks) (mean (SD)) | 120 (208) | 111 (209) | 94 (202) | 0.205 |
Days since deterioration of angina (mean (SD)) | 80 (198) | 79 (181) | 65 (127) | 0.524 |
Drug treatment at screening
| | | | |
β Blockers | 52.3% | 49.2% | 51.5% | 0.321 |
Calcium antagonists | 65.4% | 70.4%1-150
| 72.3%1-150
|
0.016
|
Nitrates | 62.1% | 66.7% | 66.2% | 0.659 |
Anticoagulants | 0.8% | 1.5% | 2.5% | 0.067 |
Platelet inhibitor | 64.3% | 63.5% | 67.7% | 0.203 |
Aspirin | 77.9% | 83.4%1-150
| 83.1%1-150
|
0.032
|
Persantin | 10.6% | 11.6% | 15.2% | 0.121 |
Laboratory investigations (mean (SD))
| | | |
Haemoglobin (g/dl) | 8.72 (0.86) | 8.89 (0.80) | 8.99 (0.86)1-150
|
0.000 |
Packed cell volume (%) | 41 (4) | 42 (4) | 43 (4)1-150
|
0.000
|
White cell count (G/l) | 7.05 (2.94) | 7.34 (2.09) | 8.26 (2.24)1-150
1-151
|
0.000 |
Platelet count (G/l) | 260 (80) | 255 (66) | 258 (70) | 0.276 |
Total cholesterol (mmol/l) | 5.88 (1.31) | 5.80 (1.21) | 5.88 (1.20) | 0.249 |
HDL cholesterol (mmol/l) | 1.20 (0.34) | 1.13 (0.56) | 1.11 (0.69) | 0.477 |
LDL cholesterol (mmol/l) | 4.15 (1.18) | 4.16 (1.33) | 3.94 (1.20) | 0.519 |