A molecular view of drug metabolism
| CYP3A4 | CYP2D6 | CYP2C9 | P-glycoprotein | |
| • Substrates | Amiodarone Quinidine Many HMG CoA reductase inhibitors (statins) Terfenadine, astemizole Cisapride Many calcium channel blockers Lidocaine, mexiletine Cyclosporine Many HIV protease inhibitors Sildenafil | Propafenone Flecainide Codeine Timolol Metoprolol Popranolol | Warfarin | Digoxin Many antineoplastic agents |
| • Inhibitors | Amiodarone Verapamil Cyclosporine, erythromycin, clarithromycin Ketaconazole, itraconazole Mibefradil, other calcium channel blockers Ritonavir | Quinidine Propafenone TCAs Fluoxetine | Amiodarone | Quinidine Amiodarone Verapamil Cyclosporine Erythromycin Ketaconazole Itraconazole |
| • Inducers | Rifampin Phenytoin Phenobarbital |
TCAs, tricyclic antidepressants.