Clinical studies on in-stent restenosis
| Author | Year | Number of lesions | Type of study | Device | Lesion length (mm) 2-152 | Angio follow up (%) | Restenosis rate | Clinical follow up (months) 2-152 | TLR (%) | Notes | |
| Baimet al 10 | 1993 | 105 | Reg | PTCA | – | 47.6 | 54 | 7.0 (6.3) | 30 | ||
| Gordon et al 11 | 1993 | 30 | Reg | PTCA | – | 46.6 | 57 | 6.8 (4.6) | – | ||
| Schoemig et al 12 | 1994 | 31 | Reg | PTCA | 18.6 (9.4) | 84 | 38.5 | 5.2 (2.4) | – | ||
| Macanderet al 9 | 1994 | 75 | Reg | PTCA | – | 38 | 30 | 5.4 (3.4) | 26 | ||
| Reimers et al 13 | 1997 | 127 | Reg | PTCA | 12.5 (7.5) | – | – | 27.4 (14.7) | 11 | Focal lesions 62%; stents (13), RA (4), ELCA (2) | |
| Bauters et al 14 | 1998 | 107 | Reg | PTCA | – | 85 | 22 | 6.3 (2.1) | 17 | Focal disease 71%; stents (14 lesions, 13%) | |
| Eltchaninoff et al 15 | 1998 | 52 | Reg | PTCA | 16 (8) | 92 | 54 | 5.3 (3.5) | 35 | Diffuse disease 71% | |
| Bossiet al 16 | 1999 | 262 | Reg | PTCA | – | – | – | 6 | 9.42-150 v19.42-151 | ||
| 12 | 15.22-150 v 31.82-151 | Non-elective stenting 11% | |||||||||
| Yokoi et al 17 | 1999 | 320 | Reg | PTCA | – | – | 51 | – | – | 2nd, 3rd, 4th, 5th, recurrent ISR 68%, 78%, 74%, 92%, respectively | |
| Jolly et al 18 | 1999 | 202 | Reg | PTCA (155) | 10.5 (9.2) | – | – | 8 (median) | 22 | TLR with RA 16%v 21% with PTCA (p = 0.87) | |
| RA (33) | 13.4 (10.1) | ||||||||||
| Stent (14) | 11.2 (10.3) | ||||||||||
| Mehran et al 21 | 1999 | 357 | Retr match | PTCAv stent | 7.3 (2.1)v 8.1 (1.3) (NS) | – | – | 12 | 25v 27 (NS) | Focal restenosis; more frequent in-hospital non-Q MI in stent group | |
| Wolf et al 22 | 1999 | 225 | Reg | PTCA | <5 mm v >5 mm | 100 | 27.9v 44.3 | 5.0 (2.9) | 27.9v 39 | ||
| Nakamura et al 24 | 1998 | 167 | Reg | CB | 17.2 (10.5) | 72 | 29 | 4.7 (2.5) | 22 | ||
| Chevalieret al 25 | 1999 | 45 | Rand | PTCAv CB | – | – | 9 | 20v 12 (NS) | Diffuse disease | ||
| Mizobeet al 26 | 1999 | 50 | Rand | CBv PTCA | – | 100 | 7.7v 32 (p=0.028) | 6 | 3.8v 28 (p=0.047) | Rerestenotic lesions after PTCA for in-stent restenosis; IVUS guided CB | |
| Adamianet al 27 | 1999 | 242 | Retr match | CB | – | 70 | 25 | 6.2 (2.6) | 18 | ||
| RA | 71 | 34 | 27 | ||||||||
| PTCA | 83 | 43 | 29 | ||||||||
| Goldberget al, BARASTER Registry32 | 1997 | 153 | Reg | RA | 21 (12) | – | – | 6 (3) | 40 | Diffuse disease 85%; stand alone RA 28% (TLR 67% v 42% when adjunctive PTCA was done) | |
| Sharma et al 33 | 1998 | 100 | Reg | RA (+adjunct PTCA) | 17 (11) | – | – | 13 (5) | 26 | Diffuse disease 81% | |
| Lee et al 34 | 1998 | 81 | Reg | RA+PTCA | 15 (7) | – | – | 9.2 (3.6) | 0 | Diffuse disease | |
| PTCA alone | 13 (6) | 4.5 | |||||||||
| Nodaet al 35 | 1999 | 344 | Reg | PTCA or RA | – | – | B-1: 36; R-1:42 (NS) | – | B-1: 25; R-1:23 (NS) | ||
| First ISR vsecond ISR | B-2:72 R-2:82 (NS) | B-2:47; R-2:72 (NS) | |||||||||
| Dauermann et al 36 | 1998 | 60 | Reg | PTCAv RA | 13.5 (8.3) | – | – | 11 (median) | 43 | Diffuse restenosis | |
| PTCA vDCA | 18.4 (13.2) | 27 (NS) | |||||||||
| Vom Dahlet al 31 | 1999 | 100 | Reg | RA+PTCA | 21 (8) | 72 | 49 | 5 (4) | 35 | ||
| Radke et al 30 | 1999 | 49 | Reg | RA+PTCA | 22.4 (20.2) | 89 | 45 | 6.6 (2.5) | 38 | Diffuse disease | |
| Vom Dahlet al, for ARTIST37 | 1999 | 298 | Rand | RAv PTCA | – | – | – | 6 | 70v 51 | Diffuse disease | |
| Sharmaet al, for ROSTER38 | 1999 | 150 | Rand | RAv PTCA | – | – | – | 12 (4) | 20v 43 | End point: clinical restenosis | |
↵2-150 Focal restenosis.
↵2-151 Diffuse restenosis.
↵2-152 Mean (SD).
Angio, angiographic; CB, cutting balloon angioplasty; ELCA, excimer laser catheter angioplasty; ISR, in-stent restenosis ; IVUS, intravascular ultrasound; PTCA, percutaneous transluminal coronary angioplasty; RA, rotational atherectomy; Rand, randomised study; Reg, registry; Retr match, retrospective matched study; TLR, target lesion revascularisation.