Intensity of anticoagulation
|
European Society of Cardiology 19952
INR range |
British Society of Haematology1
target INR |
AHA/ACC 19987
INR range | |
| Mechanical valve: first generation (eg. Starr-Edwards, Björk-Shiley standard); second generation (St Jude Medical, Medtronic Hall, BS Monostrut) | 3.0–4.5 | 3.5 in all patients with mechanical prostheses | 2.5–3.5 |
| Aortic position | 2.5–3.0 | 2.0–3.02-150 | |
| Mitral position | 3.0–3.5 | 2.5–3.5 | |
| Bioprostheses sinus rhythm | |||
| Aortic position | 2.5–3.0 | Aspirin 80–100 mg | |
| Mitral position | 3.0–3.5 | 2.5 | Aspirin 80–100 mg |
| No AC after 3 months | No AC after 3 months | No AC after 3 months | |
| Bioprostheses and atrial fibrillation | 3.0–4.5 | 2.5 | AVR + RF 2.0–3.0 |
| MVR + RF 2.5–3.5 | |||
| Rheumatic valvar heart disease and atrial fibrillation | 3.0–4.5 | 2.5 | |
| Patients with recurrent emboli under adequate anticoagulation | 3.0–4.5 + 100 mg aspirin | ||
| Non-valvar atrial fibrillation with risk factors | 2.0–3.0 | 2.5 |
↵2-150 With RF 2.5–3.5; AC, anticoagulation; AVR, aortic valve replacement; MVR, mitral valve replacement; RF, risk factors