Table 2

Intensity of anticoagulation

European Society of Cardiology 19952
INR range
British Society of Haematology1
target INR
AHA/ACC 19987
INR range
Mechanical valve: first generation (eg. Starr-Edwards, Björk-Shiley standard); second generation (St Jude Medical, Medtronic Hall, BS Monostrut)3.0–4.53.5 in all patients with mechanical prostheses2.5–3.5
  Aortic position2.5–3.02.0–3.02-150
  Mitral position3.0–3.52.5–3.5
Bioprostheses sinus rhythm
  Aortic position2.5–3.0Aspirin 80–100 mg
  Mitral position3.0–3.52.5Aspirin 80–100 mg
No AC after 3 monthsNo AC after 3 monthsNo AC after 3 months
Bioprostheses and atrial fibrillation3.0–4.52.5AVR + RF 2.0–3.0
MVR + RF 2.5–3.5
Rheumatic valvar heart disease and atrial fibrillation3.0–4.52.5
Patients with recurrent emboli under adequate anticoagulation3.0–4.5 + 100 mg aspirin
Non-valvar atrial fibrillation with risk factors2.0–3.02.5
  • 2-150 With RF 2.5–3.5; AC, anticoagulation; AVR, aortic valve replacement; MVR, mitral valve replacement; RF, risk factors