Table 2

Mean values of septal and left lateral atrioventricular plane motion

Baseline 3 months p Value 6 months p Value 12 months p Value ANOVA
Placebo/metoprolol (n)12/2910/2110/2811/27
Heart rate (ms)P88 (14)83 (15)83 (16)83 (14)0.39
M82 (18)69 (15)< 0.0567 (14)< 0.0569 (18)< 0.05< 0.001
Ejection time (ms)P203 (48)224 (29)215 (48)220 (44)0.95
M223 (37)240 (33)NS252 (38)< 0.05254 (41)< 0.050.017
Rapid filling time (ms)P58 (13)69 (29)68 (269)66 (22)0.62
M73 (38)103 (57)< 0.05113 (52)< 0.05117 (67)< 0.050.004
Total diastolic time (ms)P360 (104)383 (137)398 (150)390 (116)0.13
M415 (155)526 (189)< 0.05557 (162)< 0.05543 (200)< 0.050.003
AVP-FS (%)P4.6 (2.0)5.7 (1.7)5.0 (2.1)5.3 (2.3)0.92
M5.3 (2.0)7.1 (3.2)< 0.057.7 (3.0)< 0.057.8 (3.1)< 0.050.003
Rapid filling amplitude (mm)P1.7 (0.74)2.3 (1.0)1.8 (0.77)2.1 (0.94)0.78
M2.4 (1.3)3.3 (1.9)< 0.053.2 (1.5)< 0.054.1 (2.8)< 0.05< 0.001
Atrial filling fraction (%)P68 (27)74 (27)70 (43)58 (30)0.24
M65 (20)59 (22)< 0.0561 (22)< 0.0558 (22)< 0.050.031
Maximum ejection, dD/dt (cm/s)P2.9 (0.9)2.9 (0.8)2.9 (0.8)2.8 (1.0)0.62
M3.1 (0.8)3.6 (1.4)< 0.053.9 (1.3)< 0.053.9 (1.2)< 0.05< 0.001
Maximum rapid filling, dD/dt (cm/s)P3.7 (1.3)3.8 (1.3)3.4 (0.9)3.7 (1.6)0.67
M4.4 (1.8)4.8 (2.8)< 0.054.2 (2.0)< 0.055.2 (2.8)< 0.050.012
  • Values are mean (SD) unless stated otherwise. ANOVA column denotes significance of testing a repeated measurements analysis of variance test within respective group, followed by comparison with baseline value using Dunnett's test; –, no test performed.

  • AVP-FS, systolic fractional shortening in the atrioventricular plane; M, metoprolol; P, placebo.