Echocardiographic short axis data
| Baseline | 3 months | p Value | 6 months | p Value | 12 months | p Value | ANOVA | |||
|---|---|---|---|---|---|---|---|---|---|---|
| Placebo/metoprolol (n) | 12/29 | 10/21 | 10/28 | 11/27 | ||||||
| Interventricular septum wall thickening (mm) | P | −0.1 (1.2) | 0.3 (0.77) | – | 0.3 (0.97) | – | 0.3 (1.3) | – | 0.87 | |
| M | 0.5 (1.2) | 0.7 (1.5) | – | 0.7 (1.8) | – | 0.6 (1.1) | – | 0.35 | ||
| Posterior wall thickening (mm) | P | 4.1 (2.2) | 3.4 (2.1) | – | 4.1 (2.0) | – | 3.9 (1.5) | – | 0.83 | |
| M | 3.3 (2.1) | 4.1 (2.1) | < 0.05 | 4.0 (2.4) | < 0.05 | 4.7 (2.0) | < 0.05 | 0.006 | ||
| Fractional shortening (%) | P | 13 (2.1) | 13 (2.9) | – | 14 (4.7) | – | 14 (4.9) | – | 0.71 | |
| M | 12 (4.6) | 16 (5.7) | < 0.05 | 16 (6.4) | < 0.05 | 17 (5.8) | < 0.05 | < 0.001 | ||
| Maximum left ventricular ejection, dD/dt (cm/s) | P | 4.1 (1.0) | 4.4 (0.83) | – | 4.6 (1.1) | – | 4.8 (0.82) | – | 0.32 | |
| M | 4.5 (1.2) | 5.0 (1.6) | – | 5.1 (1.7) | – | 5.3 (1.4) | – | 0.11 | ||
| Maximum left ventricular filling, dD/dt (cm/s) | P | 8.3 (2.6) | 8.8 (2.2) | – | 8.3 (2.4) | – | 8.9 (2.4) | – | 0.95 | |
| M | 8.3 (2.6) | 9.1 (4.0) | – | 8.2 (2.8) | – | 8.9 (3.0) | – | 0.74 | ||
| Maximum interventricular septal wall thickening, dD/dt (cm/s) | P | 1.6 (0.46) | 1.7 (0.83) | – | 2.0 (0.60) | – | 2.0 (0.66) | – | 0.09 | |
| M | 2.1 (1.1) | 2.2 (1.4) | – | 2.3 (1.1) | – | 2.2 (0.94) | – | 1.00 | ||
| Maximum interventricular septal wall thinning, dD/dt (cm/s) | P | 1.3 (0.91) | 1.6 (0.90) | NS | 1.7 (1.1) | NS | 2.2 (1.0) | < 0.05 | 0.02 | |
| M | 1.7 (1.2) | 2.0 (1.8) | – | 2.0 (1.3) | – | 2.3 (1.4) | – | 1.00 | ||
| Maximum posterior wall thickening, dD/dt (cm/s) | P | 3.1 (0.87) | 3.2 (1.1) | – | 3.2 (0.89) | – | 3.2 (0.91) | – | 0.95 | |
| M | 3.0 (1.1) | 3.5 (1.1) | – | 3.1 (1.1) | – | 3.5 (1.0) | – | 0.52 | ||
| Maximum posterior wall thinning, dD/dt (cm/s) | P | 5.9 (1.7) | 5.3 (2.4) | – | 5.1 (1.6) | – | 5.6 (1.6) | – | 0.44 | |
| M | 5.3 (1.9) | 5.9 (2.8) | – | 5.0 (2.0) | – | 5.6 (1.8) | – | 0.74 | ||
ANOVA column denotes significance of testing a repeated measurements analysis of variance within respective group, followed by comparison with baseline value using Dunnett's test; –, no test performed.
M, metoprolol; P, placebo.