Thrombolytic regimens for massive pulmonary embolism
| Streptokinase | 250000 to 500000 U as a loading dose over 15 mins, followed by 100 000 U/h for 24 hours |
| Urokinase | 4400 U/kg as a loading dose over 10 min, followed by 4400 U/kg/h for 12 hours |
| rt-PA | 10 mg as a bolus, followed by 90 mg in a continuous infusion over 2 hours |
| APSAC | 30 mg in 5 mins |
| Reteplase | Two bolus injections of 10 U, 30 mins apart |
Before treatment, stop heparin