Baseline characteristics according to the ACE and AT1R genotypes
| ACE DD genotype: | − | + | − | + | p Value | |
|---|---|---|---|---|---|---|
| AT1R CC genotype: | − | − | + | + | ||
| Number of patients | 522 | 180 | 47 | 25 | ||
| Age (years) | 56 (8) | 56 (8) | 56 (8) | 56 (8) | 0.99 | |
| BMI (kg/m2) | 26.0 (2.7) | 26.0 (2.6) | 26.3 (2.5) | 25.9 (3.3) | 0.93 | |
| Ever smoked (%) | 89 | 85 | 86 | 88 | 0.67 | |
| SBP (mm Hg) | 135 (19) | 136 (19) | 136 (15) | 134 (19) | 0.89 | |
| DBP (mm Hg) | 81 (10) | 82 (10) | 83 (9) | 81 (8) | 0.75 | |
| Total cholesterol (mmol/l) | 6.0 (0.9) | 6.1 (0.9) | 6.0 (0.8) | 6.1 (0.8) | 0.66 | |
| LDL cholesterol (mmol/l) | 4.3 (0.8) | 4.3 (0.8) | 4.2 (0.7) | 4.4 (0.7) | 0.75 | |
| HDL cholesterol (mmol/l) | 0.93 (0.23) | 0.91 (0.22) | 0.91 (0.19) | 0.94 (0.25) | 0.85 | |
| Triglycerides (mmol/l) | 1.79 (0.77) | 1.88 (0.76) | 1.76 (0.77) | 1.70 (0.83) | 0.50 | |
| Baseline MSD (mm) | 2.72 (0.36) | 2.75 (0.40) | 2.75 (0.43) | 2.71 (0.38) | 0.86 | |
| Baseline MOD (mm) | 1.75 (0.35) | 1.76 (0.36) | 1.83 (0.41) | 1.68 (0.28) | 0.39 | |
| Ejection fraction (%) | 71 (12) | 70 (12) | 70 (14) | 70 (14) | 0.97 | |
| Extent of heart disease (%) | ||||||
| 1 vessel | 42 | 43 | 51 | 24 | ||
| 2 vessels | 35 | 32 | 21 | 40 | 0.26 | |
| 3 vessels | 23 | 25 | 28 | 36 | ||
| β Blocking agent (%) | 74 | 74 | 75 | 80 | 0.93 | |
| Calcium antagonist (%) | 60 | 61 | 64 | 48 | 0.61 | |
| Nitrates (%) | 56 | 52 | 57 | 56 | 0.80 | |
Values are mean (SD) unless stated otherwise.
ACE, angiotensin converting enzyme; AT1R, angiotensin II type 1 receptor; BMI, body mass index; DBP, diastolic blood pressure; HDL, high density lipoprotein; LDL, low density lipoprotein; MOD, minimum obstruction diameter; MSD, mean segment diameter; SBP, systolic blood pressure.