Table 1

Clinical features in patients with systolic and isolated diastolic heart failure

Systolic heart failure (n=46) Isolated diastolic heart failure (n=31)
Age (years)65.7 (1.8)66.5 (1.5)
Sex (M:F) (%)72:2881:19
NYHA class (%)
 II77.183.3
 III20.016.7
 IV2.9
Aetiology of heart failure
 Ischaemic heart disease84.187.9
 Dilated cardiomyopathy9.19.1
 Hypertension4.5
 Valvar heart disease3.0
 Alcoholic cardiomyopathy2.3
Drugs
 Diuretics71.460.6
 ACE inhibitors76.281.8
 β Blockers21.138.9
 Nitrates69.471.4
 Calcium channel blockers14.323.1
 Lipid lowering agents47.666.7
 Aspirin68.278.8
 Digoxin14.33.1
LV diameter, diastole (cm)6.1 (0.2)5.1 (0.1)1-150
LV diameter, systole (cm)5.0 (0.2)3.6 (0.1)1-150
Fractional shortening (%)16.5 (0.6)29.8 (1.1)1-150
LVEF (%)40.3 (1.3)65.5 (1.6)1-150
Diastolic function (%)
 RFP36.43.01-151
 Non-RFP63.697.0
Plasma adrenomedullin (pmol/l)57.0 (9.9)33.4 (6.1)
  • Values are mean (SEM) or %.

  • 1-150 p < 0.001 v patients with systolic and isolated diastolic heart failure.

  • 1-151 χ2 = 10.7, p = 0.001 vpatients with systolic and isolated diastolic heart failure.

  • ACE, angiotensin converting enzyme; LV, left ventricular; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; RFP, restrictive filling pattern.