Clinical features in patients with systolic and isolated diastolic heart failure
Systolic heart failure (n=46) | Isolated diastolic heart failure (n=31) | |
Age (years) | 65.7 (1.8) | 66.5 (1.5) |
Sex (M:F) (%) | 72:28 | 81:19 |
NYHA class (%) | ||
II | 77.1 | 83.3 |
III | 20.0 | 16.7 |
IV | 2.9 | – |
Aetiology of heart failure | ||
Ischaemic heart disease | 84.1 | 87.9 |
Dilated cardiomyopathy | 9.1 | 9.1 |
Hypertension | 4.5 | – |
Valvar heart disease | – | 3.0 |
Alcoholic cardiomyopathy | 2.3 | – |
Drugs | ||
Diuretics | 71.4 | 60.6 |
ACE inhibitors | 76.2 | 81.8 |
β Blockers | 21.1 | 38.9 |
Nitrates | 69.4 | 71.4 |
Calcium channel blockers | 14.3 | 23.1 |
Lipid lowering agents | 47.6 | 66.7 |
Aspirin | 68.2 | 78.8 |
Digoxin | 14.3 | 3.1 |
LV diameter, diastole (cm) | 6.1 (0.2) | 5.1 (0.1)1-150 |
LV diameter, systole (cm) | 5.0 (0.2) | 3.6 (0.1)1-150 |
Fractional shortening (%) | 16.5 (0.6) | 29.8 (1.1)1-150 |
LVEF (%) | 40.3 (1.3) | 65.5 (1.6)1-150 |
Diastolic function (%) | ||
RFP | 36.4 | 3.01-151 |
Non-RFP | 63.6 | 97.0 |
Plasma adrenomedullin (pmol/l) | 57.0 (9.9) | 33.4 (6.1) |
Values are mean (SEM) or %.
↵1-150 p < 0.001 v patients with systolic and isolated diastolic heart failure.
↵1-151 χ2 = 10.7, p = 0.001 vpatients with systolic and isolated diastolic heart failure.
ACE, angiotensin converting enzyme; LV, left ventricular; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; RFP, restrictive filling pattern.