Clinical features in patients with systolic and isolated diastolic heart failure
| Systolic heart failure (n=46) | Isolated diastolic heart failure (n=31) | |
| Age (years) | 65.7 (1.8) | 66.5 (1.5) |
| Sex (M:F) (%) | 72:28 | 81:19 |
| NYHA class (%) | ||
| II | 77.1 | 83.3 |
| III | 20.0 | 16.7 |
| IV | 2.9 | – |
| Aetiology of heart failure | ||
| Ischaemic heart disease | 84.1 | 87.9 |
| Dilated cardiomyopathy | 9.1 | 9.1 |
| Hypertension | 4.5 | – |
| Valvar heart disease | – | 3.0 |
| Alcoholic cardiomyopathy | 2.3 | – |
| Drugs | ||
| Diuretics | 71.4 | 60.6 |
| ACE inhibitors | 76.2 | 81.8 |
| β Blockers | 21.1 | 38.9 |
| Nitrates | 69.4 | 71.4 |
| Calcium channel blockers | 14.3 | 23.1 |
| Lipid lowering agents | 47.6 | 66.7 |
| Aspirin | 68.2 | 78.8 |
| Digoxin | 14.3 | 3.1 |
| LV diameter, diastole (cm) | 6.1 (0.2) | 5.1 (0.1)1-150 |
| LV diameter, systole (cm) | 5.0 (0.2) | 3.6 (0.1)1-150 |
| Fractional shortening (%) | 16.5 (0.6) | 29.8 (1.1)1-150 |
| LVEF (%) | 40.3 (1.3) | 65.5 (1.6)1-150 |
| Diastolic function (%) | ||
| RFP | 36.4 | 3.01-151 |
| Non-RFP | 63.6 | 97.0 |
| Plasma adrenomedullin (pmol/l) | 57.0 (9.9) | 33.4 (6.1) |
Values are mean (SEM) or %.
↵1-150 p < 0.001 v patients with systolic and isolated diastolic heart failure.
↵1-151 χ2 = 10.7, p = 0.001 vpatients with systolic and isolated diastolic heart failure.
ACE, angiotensin converting enzyme; LV, left ventricular; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; RFP, restrictive filling pattern.