Selected long term prospective studies of HIV related cardiovascular disease
| Author/study/date | n | Patients | Follow up (years) | Major findings |
| Children | ||||
| Lipshultz/ P2C2/20006 | 193 | Vertical transmission median age 2.1 years | 5 | Lower left ventricular fractional shortening (p ⩽ 0.001) and increased wall thickness (p ⩽ 0.004) independently predict mortality |
| Adults | ||||
| Barbaro/GISCA/19984 | 952 | Asymptomatic patients with HIV infection | 5 | 8% dilated cardiomyopathy over 60 months. Mean annual incidence 15.9 cases/1000 patients. Dilated cardiomyopathy associated with decreased CD4 count and zidovudine use |
| Heidenreich/199515 | 231 | HIV infected adults | 5 | Pericardial effusion 11%/year in AIDS patients. Survival of AIDS patients with effusion 36% at 6 months compared with 93% at 6 months in those without effusion |
| Currie/199416 | 296 | HIV infected adults mean age 32.7 years | 4 | Dilated cardiomyopathy associated with low CD4 count. Significantly decreased survival in those with dilated cardiomyopathy compared to those with normal hearts at similar infection stage |