Table 1

Exclusion criteria

•  Recent (< 6 weeks) myocardial infarction or unstable angina
•  Supraventricular tachycardia other than atrioventricular re-entrant tachycardia
•  Ventricular tachycardia at prestudy evaluation or at baseline electrophysiological evaluation
•  Left ventricular ejection fraction < 20%
•  Antiarrhythmic treatment or use of any other drugs that prolong the QTc interval taken within five half lives of start of study
•  Amiodarone treatment taken within 4 weeks of start of the study or a serum amiodarone concentration of> 0.4 mg/l
•  Resting QTc interval > 440 ms in a drug-free state and in the absence of pre-excitation or bundle branch block
•  Resting supine diastolic blood pressure > 110 mm Hg
•  Resting supine systolic blood pressure < 90 or > 200 mm Hg